Inhibition of Food Intake by CRF in Chickens

Denbow, D. Michael; Snapir, N.; Furuse, Mitsuhiro

doi:10.1016/s0031-9384(98)00340-0

Cited by 82 publications

(22 citation statements)

References 18 publications

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“…Hypodipsia following i.c.v. CRF/Ucn 1 similarly was reported in mice, rats, chickens, and sheep (Denbow et al, 1999;Weisinger et al, 2000;Inoue et al, 2003). The peptides' anorectic effects were not secondary to hypodipsia since they were retained in pica testing, during which water was not provided.…”

Section: Discussionsupporting

confidence: 56%

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity

Zorrilla

Reinhardt²,

Valdez³

et al. 2004

J Pharmacol Exp Ther

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Two corticotropin-releasing factor (CRF) receptor families have been identified (CRF 1 and CRF 2 ). Whereas anxiogenic-like roles for the CRF 1 receptor have been identified, behavioral functions of the CRF 2 receptor remain obscure. Urocortin 2 (Ucn 2), a CRF-related peptide that selectively binds CRF 2 receptors, was recently identified and recognized for its central anorectic properties. The present study tested the hypothesis that the anorexigenic mode of action of Ucn 2 differed from that of ovine CRF (oCRF), a preferential CRF 1 receptor agonist. The behavioral effects of intracerebroventricular administration of Ucn 2 were compared with those of oCRF in nondeprived male Wistar rats (n ϭ 102). Ucn 2 reduced 6-h food and water intake at doses that did not induce visceral illness (0.1, 1, and 10 g), as indicated by kaolin intake. Ucn 2 retained its potent anorectic activity in rats receiving a highly palatable cafeteria diet, preferentially reducing intake of carbohydrate (CHO)-rich items while sparing intake of mixed-fat/CHO items. In contrast to Ucn 2, oCRF (10 g) suppressed 6-h intake of cafeteria diet-fed rats without regard to macronutrient composition. Rather, oCRF most potently suppressed intake of preferred food items. Whereas oCRF had short-onset motor-activating effects, Ucn 2 had nondose-dependent, delayed-onset motor-suppressing effects. Thus, central infusion of a CRF 2 receptor agonist suppressed intake of both bland and palatable diets without inducing behavioral arousal or malaise, and the profile of anorexigenic effects qualitatively differed from those of a CRF 1 receptor agonist. The results suggest the existence of distinct forms of CRF 1 -and CRF 2 -mediated anorexia.

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Section: Discussionsupporting

confidence: 56%

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity

Zorrilla

Reinhardt²,

Valdez³

et al. 2004

J Pharmacol Exp Ther

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“…In birds, CRF-containing neurons are found in BSTL and other limbic regions (e.g., PoA, TnA, hippocampal formation, and CDL) (Péczely and Antoni, 1984;Ball et al, 1989;Richard et al, 2004). Furthermore, subcutaneous or intracerebroventricular injection of CRF decreases the number of distress vocalization of isolated quail chicks, decreases food intake in the chicken, territorial defense in the male white-crown sparrow, suppresses courtship behavior in the female, and decreases schedulecontrolled key pecking in pigeons (Barrett et al, 1989;Launay et al, 1993;Maney and Wingfield, 1998;Romero et al, 1998;Denbow et al, 1999;Ohgushi et al, 2001). Thus, CRF has functions mediating appetite, sexual behavior, social behavior, and learning in birds.…”

Section: Functional Implications Of the Avian Poac And Bstlmentioning

confidence: 99%

Fiber connections of the compact division of the posterior pallial amygdala and lateral part of the bed nucleus of the stria terminalis in the pigeon (Columba livia)

Atoji

Saito

Wild

2006

J of Comparative Neurology

140

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The compact division of the posterior pallial amygdala (PoAc) and lateral part of the bed nucleus of the stria terminalis (BSTL) are components of the limbic system in the pigeon brain. In this study, we examined the position and fiber connections of these two nuclei by using Nissl staining and tract-tracing methods. PoAc occupies a central division in the posterior pallial amygdala. BSTL faces the ventral horn of the lateral ventricle and extends between A 7.25 and A 10.50. PoAc and BSTL connect bidirectionally by the stria terminalis. PoAc connects reciprocally with two nuclear groups in the cerebrum: 1) a continuum consisting of the caudoventral nidopallium, lateral part of the caudoventral nidopallium (NCVl), subnidopallium beneath NCVl, and piriform cortex and 2) rostral areas of the hemisphere, including the frontolateral and frontomedial nidopallium and the densocellular part of the hyperpallium. Extratelencephalic projections of PoAc terminate in the dorsomedial thalamic nuclei and reach the lateral hypothalamic area via the hypothalamic part of the occipito-mesencephalic tract. BSTL also connects reciprocally with two main regions: 1) the same continuum as for PoAc projections, except the piriform cortex and 2) rostral areas of the hemisphere, including the olfactory tubercle and nucleus accumbens. Extratelencephalic reciprocal connections are with the substantia nigra, nucleus subceruleus dorsalis, parabrachial nucleus, locus coeruleus, and nucleus of the solitary tract. The dorsomedial subdivision of the hippocampal formation projects massively to PoAc and BSTL. These findings indicate that PoAc and BSTL are important components of an interconnected neural circuit involving widespread regions of the neuraxis and mediating limbic-visceral functions.

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“…In the case of CRF-induced behavioral responses, there is a remarkable degree of conservation among vertebrates with respect to the eVects of CRF on several behaviors that have been studied including, notably, ingestive, and reproductive behaviors. CRF decreases ingestive behaviors in Wsh (reviewed in Bernier and Peter (2001); VolkoV et al (2005)), amphibians , birds (Denbow et al, 1999;Furuse et al, 1997;Ohgushi et al, 2001;Richardson et al, 2000;Zhang et al, 2001a,b), and mammals (reviewed in (Dunn and Berridge, 1990)). In amphibians, this has been extended to include prey-catching behaviors (Carr et al, 2002).…”

Section: Behavioral Responses To Administration Of Crfmentioning

confidence: 99%

Regulation of behavioral responses by corticotropin-releasing factor

Lowry

Moore

2006

General and Comparative Endocrinology

137

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Inhibition of Food Intake by CRF in Chickens

Cited by 82 publications

References 18 publications

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity

Fiber connections of the compact division of the posterior pallial amygdala and lateral part of the bed nucleus of the stria terminalis in the pigeon (Columba livia)

Regulation of behavioral responses by corticotropin-releasing factor

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Inhibition of Food Intake by CRF in Chickens

Cited by 82 publications

References 18 publications

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2Agonist, and Ovine CRF, a CRF1Agonist, Differentially Alter Feeding and Motor Activity

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2Agonist, and Ovine CRF, a CRF1Agonist, Differentially Alter Feeding and Motor Activity

Fiber connections of the compact division of the posterior pallial amygdala and lateral part of the bed nucleus of the stria terminalis in the pigeon (Columba livia)

Regulation of behavioral responses by corticotropin-releasing factor

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Resources

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Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity

Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂Agonist, and Ovine CRF, a CRF₁Agonist, Differentially Alter Feeding and Motor Activity