Inhibition of Focal Adhesion Kinase Suppresses Adverse Features of Endocrine-Resistant Breast Cancer Cells and Improves Endocrine Response in ER+, Endocrine-Sensitive Cells.
Abstract:Background: Focal adhesion kinase (FAK) regulates signalling pathways central to cell adhesion, migration and survival and its expression is frequently deregulated in cancer, including breast cancer. Acquired resistance to endocrine therapy in breast cancer is a major clinical problem: relapses present as local and/or regional recurrences, frequently with metastases and the outlook for these patients is poor. Interestingly, cell models of acquired endocrine resistance have altered cell-matrix adhesion and a hi… Show more
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