“…Several studies by others have reported the existence of small molecules that bind to γ-crystallins, including lanosterol ( 59 ), cochineal carmine ( 60 ), ortho-Vanilin ( 61 ), quercetin ( 62 ), hesperetin ( 63 ), and sodium citrate ( 64 ). Moreover, small molecules with either demonstrated potential anticataract properties involving antiaggregation activity against crystallins include rosemarinic acid ( 65 ), morin ( 66 , 67 ), 25-hydrocholesterol ( 68 ), epigallocatechin gallate ( 69 ), and myoinositol ( 70 ). Among these compounds, those that were included in the screen included epigallocatechin gallate, which improved aggregation, whereas morin, lanosterol, hesperetin, and carmine had no impact.…”