Inhibition of Experimental Nephrocalcinosis by Hypophysectomy.

Selye, Hans; Bois, Pierre; Ventura, J

doi:10.3181/00379727-92-22521

Cited by 8 publications

(6 citation statements)

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“…This finding is in contradiction to the observation of Selye and Bois [1956] who had claimed highly beneficial effects from the use of cortisol acetate (COLA).…”

Section: Bapn No Difference Could Be Seen Between the Actions Of L-acontrasting

confidence: 55%

“…Selye [1957 b] found that the effects of thyroxine on AAN-induced lesions were evident in intact and adrenalectomized animals and he concluded that the hormone does not act by virtue of its stressor effect through the hypophysis-adrenal axis. In further studies Selye and Ventura [1957] showed that hypophysectomy inhibited the development of AAN lesions in rats and that the rats responded to AAN only when they were treated with somatotrophic hormone (STH). It is feasible, then, that the thyroid hormones might inhibit the skeletal lesions of BAPN by depressing the secretion of somatotrophic hormone from the anterior pituitary gland.…”

Section: Resultsmentioning

confidence: 99%

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Quantitative Studies on the Suppression of Skeletal Lesions in Rats Produced by Β‐aminopropionitrile

1962

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Newly weaned male albino rats were given by gavage graded doses of fl-aminopropionitrile for 4 weeks either alone or with one of the thyroid hormones viz. L-thyroxine, D-thyroxine, L-triiodothyronine and D-triiodothyronine. Some rats were given the thyroid hormones alone to see whether these hormones produced any change in the physical properties of the bones. It was found that:1. fi-aminopropionitrile (BAPN) produced a significant fall in the breaking stress and stiffness of the bones of young growing rats. The value for strain at the elastic limit was not affected. 2. The thyroid hormones did not produce any significant change in the physical properties of the femora of normal rats. 3. Thyroxine was quite a good antagonist against BAPN. At the lower doses of the nitrile it completely prevented the lesions and, at the higher doses of BAPN, it modified greatly the toxic actions of the nitrile. L-thyroxine and D-thyroxine were equally effective in their action against BAPN. L-triiodothyronine and D-triiodothyronine were equally potent in inhibiting the lesions of 50 mg. BAPN. 4. It is suggested that the action of the thyroid hormones in antagonizing BAPN is unlikely to be due to the general metabolic effects of the hormones.

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“…This finding is in contradiction to the observation of Selye and Bois [1956] who had claimed highly beneficial effects from the use of cortisol acetate (COLA).…”

Section: Bapn No Difference Could Be Seen Between the Actions Of L-acontrasting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Quantitative Studies on the Suppression of Skeletal Lesions in Rats Produced by Β‐aminopropionitrile

1962

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“…Selye et al (86) produced nephrocalcinosis in rats by the administration of sodium phosphates ; nephrocalcinosis does not develop, however, in hypo physectomized rats. Ventura & Selye (87) also show that hypophysectomy abolishes the lytic effect of deoxycorticosterone acetate on the spleen and thymus of either adrenal-intact or adrenalectomized rats.…”

Section: Anterior Pituitarymentioning

confidence: 99%

Endocrinology

Asper¹,

Wilson²

1958

Annu. Rev. Med.

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Progress in endocrinology has been rapid. So large is the field that in one year's harvest an entire chapter could be devoted to each of the endo crine glands. Remarkable achievements have been in many instances be cause of the successful application of newer techniques such as chromatog raphy, radioisotope tracer procedures, and microchemical analyses. In this review an appraisal has been made of experimental work relating to the anterior pituitary, thyroid, adrenal cortex, parathyroid, and pancreas. ANTERIOR PITUITARYMuch interest has been shown in the hormones of the anterior pituitary. Variability of experimental data pertaining to these hormones has resulted, in large measure, from the use of impure preparations and, although im proved methods of purification have become available, they remain expen sive and laborious. Highly purifi ed hormones are now obtainable for re search purposes from the Endocrinology Section of the National Institutes of Health (1), and it seems likely that'their use will lead to a better appraisal of the specifi c action of these substances.For many years attempts have been made to ascribe specific hormonal functions to the various cells of the pituitary. At first there was only con jecture, but later assignation of function to specific cell types was based on histological examination of the pituitary in patients with various glandular disorders. More recently, special stains and solvents, bioassays, and selective destruction of minute parts of the pituitary have been applied to this analy sis. Many such studies have been performed and the definitive results of a recent project are outlined by Barrnett et al.(2 ). These workers show that thyrotropic, follicle-stimulating, and luteinizing hormones are localized to those basophiles which have an affinity for periodic acid-Schiff stain.Gro wth ho rmone (GH}.-It has been recognized that growth hormone from bovine or porcine sources is ineffective in man. Indeed, a degree of 'The survey of literature pertaining to this review was completed in August, 1957.For the sake of brevity the abbreviation et ai, is used when three or more authors' names appear on a paper. S The following abbreviations are used: GH (growth hormone); ACTH (adrenocorticotropin); MSH (melanocyte-stimulating hor;mone); TSH (thyroid stimulating hormone); FSH (follicle-stimulating hormone); LH (luteinizing hormone) : PBI (protein-bound iodine) : BMR (basal metabolic rate): TBP (thy roxine-binding protein) : PTH (parathyroid hormone ) : GFR (glomerular filtration rate): Tmp (maximal rate of tubular reabsorption of phosphorus by kidney): Tmo (maximal rate of tubular reabsorption of glucose by kidney).

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“…University of Texas Medical Branch, Galveston, Texas to produce adrenal enlargement, it is instructive to note that of those used only cold has been conspicuously successful in producing hypertensive cardio¬ vascular disease in sensitized rats [Selye, 1943;Selye, 1957;Ingle 8c Baker, 1957). Cold, however, as we have pointed out [Hall 8c Hall, 1958), has the out¬ standing disadvantage of augmenting thyroid hormone secretion (Woods 8c Carlson, 1956), and thyroxine in turn not only sensitizes to the cardiovascular damage produced in the rat by corticoids [Selye 8c Bois, 1956) and vitamin D [Gillman 8c Gilbert, 1956), but also produces the same lesions when used alone [Selye, 1946). Hence cold is hardly a suitable non-specific Stressor if cardio¬ vascular lesions are to be used as indices.…”

mentioning

confidence: 91%

Augmentation of Hormone-Induced Hypertensive Cardiovascular Disease by Simultaneous Exposure to Stress

Hall

1959

Acta Endocrinologica

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Many attempts have been made to demonstrate that stressed uninephrectomized rats on a high NaCl intake develop hypertensive cardiovascular disease. This was first claimed by Selye (1943), who inferred that adrenal cortical hypersecretion was the causative factor. Recently the experimental data has been reinforced and the view as to causation reiterated (Selye, 1957, Ingle &Baker, 1957, and others). Crane et al. (1958 a) have subjected the hypothesis to careful scrutiny and concluded that while exposure to cold, or certain other stressors, produces cardiac and renal hypertrophy and a variable incidence of pathologic changes in these organs, the amount of food consumed, and particularly sodium ingested, are crucial factors. A bewildering variety of stressors has been tried. Selye et al. (1958) used restraint, pentobarbital, vagotomy, cold baths, hot baths, spinal cord transection, bone fractures, intestinal trauma, quadriplegia, adrenalin, noradrenalin, [00BB]Pitressin[00AB] and nephrectomy, in an attempt to produce cardiopathy; Crane et al. (1958 b) employed laparotomy, skin excision, hemorrhage, burns, fractures, limb ligation and formaldehyde injections, in an effort to produce hypertensive cardiovascular disease. Virtually all of the Stressors cited are known to produce shock. Their failure to produce hypertensive cardiovascular disease is there¬ fore perhaps not surprising. Although most Stressors share the ability to activate the pituitary-adrenal axis, the action of the adrenal hormones thus evoked upon the cardiovascular system is strongly conditioned, either positively or nega¬ tively, by a variety of circumstances. It seems unreasonable to expect a Stressor capable of inducing a hypotensive shock-like state, to produce hypertensive cardiovascular disease.Although it is often assumed -incorrectly -that Selye's theory requires that the property should be shared by a wide variety of Stressors having the capacity

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Inhibition of Experimental Nephrocalcinosis by Hypophysectomy.

Cited by 8 publications

References 0 publications

Quantitative Studies on the Suppression of Skeletal Lesions in Rats Produced by Β‐aminopropionitrile

Quantitative Studies on the Suppression of Skeletal Lesions in Rats Produced by Β‐aminopropionitrile

Endocrinology

Augmentation of Hormone-Induced Hypertensive Cardiovascular Disease by Simultaneous Exposure to Stress

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