Inhibition of Experimental Dental Caries Using an Intraoral Fluoride-Releasing Device

Mirth, Dale B.; Adderly, Donna D.; Amsbaugh, S.M.; Monell-Torrens, E.; Li, Shou-Hua; Bowen, William H.

doi:10.14219/jada.archive.1983.0188

Cited by 29 publications

(29 citation statements)

References 6 publications

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“…The direct comparison of the finding of this research is with the studies of Mirth et al 13,14 who showed that the use of an F containing co-polymer membrane device could release F and inhibit dental caries. However, the SFG described herein, produced a significant rise in saliva F concentrations for over 18 months.…”

Section: Discussionsupporting

confidence: 68%

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In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

Curzon

Toumba

2004

Br Dent J

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AimsThe aims were to evaluate a) whether a slow release fluorideglass pellet (SFG) would be retained in the mouth and release fluoride (F) over a long period of time, b) what concentrations of F in the glass would provide ideal intra-oral saliva F concentrations and c) whether an SFG would affect blood plasma concentrations of F after swallowing compared with ingestion of a commercial NaF tablet. Methods a) A prototype SFG was attached to a maxillary molar of a volunteer. Baseline saliva F concentrations were measured prior to glass placement, daily in week one; one day a week for weeks two to three and then one day a month up to18 months. Four subjects had the SFG for six months with saliva F concentration assessments at periodic intervals. b) SFGs containing F at 13.3%, 18.3% and 21.9%, and an improved solubility, were tested using three volunteers and saliva F concentrations measured. c) Five volunteers each swallowed either a SFG or a NaF tablet. Blood plasma samples were taken at baseline and F measured at time intervals of 2. 5,5,10,20, 30, 45, 60, 90 and 120 mins post-ingestion. Results a) The prototype SFG were successfully retained and released F into saliva; mean concentrations of 0.035 mg L -1 were achieved lasting for over 18 months.

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Section: Discussionsupporting

confidence: 68%

“…Raised intra-oral F salivary concentrations have been achieved in humans 13 and animals. 14 In humans the salivary F concentrations have been associated with a reduction in new carious lesions. 9 Leverett et al 9 showed that caries-free subjects had significantly higher salivary F when compared with high caries subjects.…”

Section: N B R I E Fmentioning

confidence: 99%

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

Curzon

Toumba

2004

Br Dent J

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“…The small or limited amounts of fluoride released indicate that this composite is very stable in water. On the other hand, various resin-bound fluoride compounds have been developed as organic components so that these do not show any noticeable deterioration by adopting some unique fluoride-releasing mechanisms [Mirth et al, 1983;Tanaka et al, 1987;Gron et al, 1989]. Some use ion-exchange reactions between fluorine ion (F -) and hydroxy ion (OH -) [Tanaka et al, 1987] or chloride ion (Cl -) [Zimmerman et al, 1984] after diffusion of water.…”

Section: Discussionmentioning

confidence: 99%

“…adopted a resin-bound fluoride compound as resin matrix (resin monomer) [Mirth et al, 1983;Tanaka et al, 1987;Gron et al, 1989]. Other products used a microencapsulated soluble salt [Temin et al, 1989;Chan et al, 1990] or dispersed sparingly soluble fluoride salts [Arends and Ruben, 1988] as their inorganic fillers.…”

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confidence: 99%

In vitro Enamel and Cementum Fluoride Uptake from Three Fluoride–Containing Composites

et al. 1998

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The incorporation of fluoride into restorations is desirable because of its cariostatic action. The purpose of this study was to determine fluoride release and fluoride uptake by enamel and cementum from three visible light–cured fluoride–containing composites. Seven circular discs of each composite were prepared and the amount of fluoride released into distilled water was determined at daily intervals for 14 days and then after 30, 60 and 90 days. The fluoride concentration in enamel and cementum was determined in three successive depths by an acid etch biopsy procedure. The composite slabs were made and ligated to the enamel and cementum surfaces and the teeth were immersed in synthetic saliva for 7 days. After removal of the composite slabs, three successive biopsies were again performed. Then the teeth were immersed in 1 M KOH for 24 h and similar biopsies done. The fluoride concentrations were adjusted to standardized depths of 10μm, and the total and bound fluoride uptake calculated. The amounts of fluoride released were significantly different among the three composites. The fluoride released decreased sharply after 1 day and then gradually reached a plateau. As for the enamel and cementum fluoride uptake, FluorEver showed the largest uptake followed by FluoroCore and then Pertac–Hybrid.

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“…Available evidence shows clearly that the cariostatic effect of fluoride is heavily dependent on its ambient levels in the mouth (Larson and Mellberg, 1977;Mirth et al , 1982Mirth et al , , 1983Corpron et al , 1986). These observations suggest that low levels of fluoride constantly present in the mouth are critical for the expression of its maximum effect (Duckworth et al , 1987;Meyerowitz and Watson, 1998).…”

Section: Enhancing the Effects Of Fluoridementioning

confidence: 99%

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

Bowen

2002

Critical Reviews in Oral Biology & Medicine

Self Cite

200

109

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ABSTRACT:Dental caries continues to be a pubic health problem despite claims that 50% of schoolchildren are caries-free. There are widespread variations in the prevalence of caries worldwide. Caries lesions are the clinical manifestation of a pathogenic process that may have been occurring on the tooth surface for months or years. Acid production by bacteria embedded in a biofilm termed "dental plaque" is a key aspect of the pathogenesis of dental caries; nevertheless, the ability of micro-organisms to survive in a hostile acid milieu and the influence of fluoride and additional agents on this acid tolerance receive scant attention. Study of cariogenic micro-organisms largely has been limited to observations made on them in the planktonic state; clearly dental caries is essentially a surface phenomenon, and micro-organisms behave distinctively when grown on a surface. Although significant progress has been made in our understanding of the etiology, pathogenesis, and prevention of dental caries, it still remains a scientific and clinical enigma worthy of the attention of the best scientists.

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Inhibition of Experimental Dental Caries Using an Intraoral Fluoride-Releasing Device

Cited by 29 publications

References 6 publications

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

In vitro Enamel and Cementum Fluoride Uptake from Three Fluoride–Containing Composites

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

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