Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid

Koide, Masanori; Okahashi, Nobuo; Tanaka, Ryusui; Kazuno, Keiko; Shibasaki, K; Yamazaki, Yohtaro; Kaneko, Kaichi; Ueda, Nobuo; Ohguchi, Masahiro; Ishihara, Yuichi; Noguchi, Toshihide; Nishihara, Tatsuji

doi:10.1016/s0003-9969(99)00067-9

Cited by 34 publications

(12 citation statements)

References 30 publications

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“…This is in agreement with typical observations of growth reduction in fishes requiring dietary taurine. This also converges with previous findings showing that taurine influences bone metabolism via a taurine-specific transporter in osteoblasts (Yuan et al, 2006), promotes connective tissue growth factor in osteoblasts (Yuan et al, 2007), and inhibits bone resorption by osteoclasts (Koide et al, 1999). Finally, (Park et al, 2001) showed that taurine stimulated ALP activity in cultured osteoblast.…”

Section: Alkaline Phosphatase and Bone Metabolismsupporting

confidence: 91%

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

et al. 2016

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Section: Alkaline Phosphatase and Bone Metabolismsupporting

confidence: 91%

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

et al. 2016

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“…Taurine (100 µg/ml) suppressed the formation of these osteoclast-like cells in the presence of LPS, IL-1α or PGE2 in mouse marrow cultures. Although IL-1α elongated the survival of the osteoclast-like cells, taurine blocked the supportive effect of IL-1α on osteoclast survival (Koide et al, 1999). In contrast, LPS decreased taurine uptake significantly in macrophage cell line, RAW 264.7 cell (Kim et al, 2003).…”

Section: Discussionmentioning

confidence: 87%

“…In bone cells, taurine is also found in high concentration (Lubec et al, 1997), and is known to help in enhancing the bone tissue formation, which was observed by increased matrix formation and collagen synthesis (Park et al, 2001). Besides stimulating the bone tissue formation, it is suggested that being incorporated in bone tissue, taurine plays an important role in bone metabolism by inhibiting experimental bone resorption, osteoclast formation, and osteoclast survival (Koide et al, 1999), however, this mechanism was not clarified yet.…”

Section: Introductionmentioning

confidence: 99%

The Change of Taurine Transport in Osteocytes by Oxidative Stress, Hypertonicity and Calcium Channel Blockers

Kang¹,

Kim²

2008

Biomolecules and Therapeutics

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− Taurine is the most abundant amino acid in many tissues and is found to be enhancing the bone tissue formation or inhibits the bone loss. Although it is reported that taurine reduces the alveolar bone loss through inhibiting the bone resorption, its functions of taurine and expression of taurine transporter (TauT) in bone have not been identified yet. The purpose of this study is to clarify the uptake mechanism of taurine in osteoblast using mouse osteoblast cell lines. In this study, mouse stromal ST2 cells and mouse osteoblast-like MC3T3-E1 cells as osteoblast cell lines were used. The activity of taurine uptake was assessed by measuring the uptake of ]taurine uptake in ST2 cells treated with 4 mM calcium was increased by 1.7-fold of the control which was a significant change. In contrast, in Ca ++ -free condition and L-type calcium channel blockers (CCBs), taurine transport to osteocyte was significantly inhibited. In oxidative stress conditions, [ 3 H]taurine uptake was decreased by TNF-α and H 2 O 2 . Under the hyperosmotic conditions, taurine uptake was increased, but inhibited by CCBs in hyperosmotic condition. These results suggest that, in mouse osteoblast cell lines, taurine uptake by TauT was increased by the presence of extracellular calcium, whereas decreased by CCBs and oxidative stresses, such as TNF-α and H 2 O 2 .

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“…On the other hand, taurine may inhibit osteoclastogenesis (Koide et al 1999), a process which has been shown to be taurine transporter dependent (Yuan et al 2010). In mesenchymal stem cells, taurine was recently reported to promote osteogenesis via Erk pathway (Zhou et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

Karjalainen

Leskelä

et al. 2014

Amino Acids

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Taurine is a small organic osmolyte which participates in cell volume regulation. Chondrocytes have been shown to accumulate and release taurine; in bone, taurine participates in bone metabolism. However, its role in skeletal cells is poorly understood, especially in chondrocytes. This study investigated the regulation of taurine transporter in chondrocytic cells. We examined the transcriptional regulation of the taurine transporter under anisotonia by reporter gene and real-time RT-PCR assays. The effect of providing supplementary taurine on cell viability was evaluated with the lactate dehydrogenase release assay. The localization of the taurine transporter in human chondrosarcoma cells was studied by overexpressing a taurine transporter-enhanced green fluorescent protein. We observed that the transcription of the taurine transporter gene was up-regulated in hypertonic conditions. Hyperosmolarity-related cell death could be partly abolished by taurine supplementation in the medium. As expected, the fluorescently labeled taurine transporter localized at the plasma membrane. In polarized epithelial MDCK cells, the strongest fluorescence signal was located in the lateral cell membrane area. We also observed that the taurine transporter gene was expressed in several human tissues and malignant cell lines. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells.

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Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid

Cited by 34 publications

References 30 publications

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

The Change of Taurine Transport in Osteocytes by Oxidative Stress, Hypertonicity and Calcium Channel Blockers

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

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