Inhibition of Experimental Allergic Encephalomyelitis by a New Anti‐Inflammatory Compound–SK&amp;F 86002

DiMartino, Michael J.; Wolff, C. E.; Campbell, Gayle; Hanna, Nabil

doi:10.1111/j.1749-6632.1988.tb27179.x

Annals of the New York Academy of Sciences

1988

DOI: 10.1111/j.1749-6632.1988.tb27179.x

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Inhibition of Experimental Allergic Encephalomyelitis by a New Anti‐Inflammatory Compound–SK&F 86002

Michael J. DiMartino¹,

C. E. Wolff²,

Gayle Campbell³

et al.

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Cited by 4 publications

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“…The role of LTs in the pathophysiology of MS remains unclear, also today (5–7). A certain biological role of LTs in MS has been suggested after experimental research in animals (8–10) and because of the finding of elevated LT concentrations in the cerebrospinal fluid (CSF) of patients with MS (7, 11, 12). Other studies, however, found normal CSF concentrations of LTs (6), and difficulties in measuring LTs accurately in body fluids have been cited as explanation for the discrepancies (6).…”

mentioning

confidence: 99%

Leukotrienes in patients with clinically active multiple sclerosis

Neu¹,

Metzger²,

Zschocke

et al. 2002

Acta Neurologica Scandinavica

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mentioning

confidence: 99%

Leukotrienes in patients with clinically active multiple sclerosis

Neu¹,

Metzger²,

Zschocke

et al. 2002

Acta Neurologica Scandinavica

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Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig

Fretland¹,

Widomski²,

Shone³

et al. 1991

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The accepted model for the human demyelinating disease, multiple sclerosis (MS), is experimental allergic encephalomyelitis (EAE). We assessed the ability of SC-41930(7-[3(4-acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]- 3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxyl acid), to modulate the symptoms of acute EAE generated in guinea pigs. Animals were pretreated with SC-41930 (20 mg/kg, i.p.) for two days followed by thrice-weekly maintenance. At day 52, a significant number of the SC-41930-treated animals were alive as compared to EAE alone. Control animals had an increase in body weight while EAE animals lost over 20% (p less than 0.5) of their body weight by day 18. SC-41930-treatment significantly reduced, but did not completely inhibit the cachectic response. The results indirectly implicate LTB4 in the pathogenesis of EAE. Agents that modify this model be useful in the treatment of human MS.

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Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis

Fretland¹

1992

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Inhibition of Experimental Allergic Encephalomyelitis by a New Anti‐Inflammatory Compound–SK&F 86002

Cited by 4 publications

References 2 publications

Leukotrienes in patients with clinically active multiple sclerosis

Leukotrienes in patients with clinically active multiple sclerosis

Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig

Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis

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