2015
DOI: 10.1007/s13277-015-4695-1
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Inhibition of epithelial-mesenchymal transition in bladder cancer cells via modulation of mTOR signalling

Abstract: Mounting evidence suggests that signalling cross-talk plays a significant role in the regulation of epithelial-mesenchymal transition (EMT) in cancer cells. However, the complex network regulating the EMT in different cancer types has not been fully described yet which affects the development of novel therapeutic strategies. In the present study, we investigated the signalling pathways involved in EMT of bladder cancer cells and demonstrated the effects of two novel agents in the regulation of EMT. Myrtucommul… Show more

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Cited by 31 publications
(21 citation statements)
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“…Meanwhile, other studies have demonstrated that thymoquinone decreased the expression of Twist1 at the transcriptional level, leading to the reversal of EMT in MDA-MB-435, BT549 and HeLa cells. In addition, thymoquinone downregulated N-cadherin, Snail and Slug expressions in bladder cancer T24 cells, which were partially in accordance with our results (20).…”
Section: Discussionsupporting
confidence: 91%
“…Meanwhile, other studies have demonstrated that thymoquinone decreased the expression of Twist1 at the transcriptional level, leading to the reversal of EMT in MDA-MB-435, BT549 and HeLa cells. In addition, thymoquinone downregulated N-cadherin, Snail and Slug expressions in bladder cancer T24 cells, which were partially in accordance with our results (20).…”
Section: Discussionsupporting
confidence: 91%
“…Therefore, TQ has been regarded as a promising agent for numerous diseases. Previous studies have revealed that TQ may exhibit high anti‐tumor efficiency against various cancers, such as breast cancer, gastric cancer, cervical cancer, colon cancer, central nervous system cancer, ovarian cancer, prostate cancer, bladder cancer and renal cell cancer . It is well known that invasion and metastasis play vital roles in the progression of tumors.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies have revealed that TQ may exhibit high anti-tumor efficiency against various cancers, such as breast cancer, gastric cancer, cervical cancer, colon cancer, central nervous system cancer, ovarian cancer, prostate cancer, bladder cancer and renal cell cancer. [10][11][12][13][14][15][16][17][18] It is well known that invasion and metastasis play vital roles in the progression of tumors. Recent research has shown that TQ can inhibit metastasis and EMT in prostate cancer via the transforming growth factor-beta/Smad2/3 signaling pathway.…”
mentioning
confidence: 99%
“…It has been evident that thymoquinone treatment inhibits TWIST1 promoter activity and decreases its expression in breast cancer cell lines; leading to the inhibition of epithelial-mesenchymal transition (EMT) mediated cancer cell migration, invasion and metastasis [ 51 ]. Along with interfering with EMT, thymoquinone also attenuated mTOR activity, and inhibited PI3K/Akt signaling in bladder cancer [ 52 , 53 ].…”
Section: Introductionmentioning
confidence: 99%