Inhibition of endogenous TSH in rats by antiserum to bovine TSH

Baschieri, L; Negri, M; Luca, F.; Sereno, L; Cramarossa, L

doi:10.1007/bf02153866

Cited by 3 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar effect on endogenous thyroid function in the rat has also been described by Baschieri et d ( 8 ) who showed that injection of 0.1 ml of immune rabbit plasma every other day for 10 days led to significant inhibition of thyroid 1131 uptake and to decrease in thyroid gland size. Cross reactivity of the antibody, recognized by a number of workers(5-7) is thus confirmed.…”

Section: Fig 1 Effect Of Anti-beef T S H Antibody (Rabbit)supporting

confidence: 76%

Acute Inhibition of Thyroid Function in the Rat Produced by Rabbit Antibody to Beef Thyrotrophic Hormone.

Reichlin¹,

Boshans²

1962

Experimental Biology and Medicine

View full text Add to dashboard Cite

Section: Fig 1 Effect Of Anti-beef T S H Antibody (Rabbit)supporting

confidence: 76%

Acute Inhibition of Thyroid Function in the Rat Produced by Rabbit Antibody to Beef Thyrotrophic Hormone.

Reichlin¹,

Boshans²

1962

Experimental Biology and Medicine

View full text Add to dashboard Cite

Inhibition of endogenous TSH in the rat by graded doses of TSH-antiplasma

Panda¹,

Turner²

1966

Metabolism

View full text Add to dashboard Cite

Neutralizing Antibodies to Bovine Thyrotropin in Immunized Patients with Thyroid Cancer*

Melmed

Harada

Herishman

et al. 1980

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Bovine thyrotropin (bTSH) was administered to 17 patients who had thyroid carcinoma. Anti-bTSH antibodies in the patients' sera were detected by three methods: 1) cross-reaction of sera in a homologous bTSH RIA, 2) [125I]bTSH binding to the patients' sera using charcoal to separate bound from free fractions, and 3) gel filtraton to detect [125I]bTSH bound to anti-bTSH in patients' sera. Immunoreactive anti-bTSH antibodies were thus demonstrated in 14 patients. These patients showed specific binding of their sera to [125I]bTSH with the charcoal separation of free from bound hormone. A high titer of antiserum (1:10,000) was found in those patients whose sera reacted strongly in the bTSH RIA (greater than 50 mu U/ml). The binding capacity of the serum of 1 patient was estimated as 2,600 mu U/ml serum. Ten of the patients' sera which showed immunoreactivity to bTSH neutralized bTSH activity in the McKenzie mouse bioassay but did not neutralize the activity of human TSH in this bioassay. Repeated administration of bTSH to 14 patients resulted in development of immunoreactive and neutralizing anti-bTSH antibodies. Development of immunological resistance to bTSH appears inevitable in patients who receive repeated injections of this hormone. Because of the loss of effectiveness of bTSH by antibody formation, the repeated diagnostic and therapeutic use of bTSH is not recommended.

show abstract

Inhibition of endogenous TSH in rats by antiserum to bovine TSH

Cited by 3 publications

References 6 publications

Acute Inhibition of Thyroid Function in the Rat Produced by Rabbit Antibody to Beef Thyrotrophic Hormone.

Acute Inhibition of Thyroid Function in the Rat Produced by Rabbit Antibody to Beef Thyrotrophic Hormone.

Inhibition of endogenous TSH in the rat by graded doses of TSH-antiplasma

Neutralizing Antibodies to Bovine Thyrotropin in Immunized Patients with Thyroid Cancer*

Contact Info

Product

Resources

About