Inhibition of endogenous dopamine release in amphibian retina byl-2-amino-4-phosphonobutyric acid (l-AP4) andtrans-2-aminocyclopentane-1,3-dicar☐ylate (ACPD)

Boatright, J.H.; Gordon, Johnthan; Iuvone, P. Michael

doi:10.1016/0006-8993(94)91084-7

Cited by 27 publications

(17 citation statements)

References 15 publications

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“…For amacrine cells with a specific neurochemical signature, such as cholinergic starburst cells and dopaminergic amacrine cells, it might be possible to detect expression of metabotropic glutamate receptors through neurochemical experiments that measure the release of their neurotransmitters. Interestingly, Boatright et al (1994) recently reported that trans-ACPD, as well as APB, can block light-stimulated dopamine release from Xenopus retina. This may reflect action at the same receptor, because trans-ACPD has been shown to be active at the APB receptor of ON-bipolar cells in lower vertebrates (Thoreson and Miller, 1994;Tian and Slaughter, 1994).…”

Section: Amacrine Cellsmentioning

confidence: 98%

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

Hartveit

Brandstätter

Enz

et al. 1995

Eur J of Neuroscience

103

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We have studied the expression of mRNAs for seven metabotropic glutamate receptors (mGluR1-7) in the retina of the adult rat by in situ hybridization with tissue sections and isolated cells using [alpha 35S]dATP-labelled oligonucleotide probes. Hybridization revealed the expression of six of the metabotropic receptor mRNAs, mGluR1, 2 and 4-7, in the retina, while mGluR3 was not detected. Each of the expressed receptor mRNAs showed a distinct pattern of expression. In the outer nuclear layer, corresponding to photoreceptor somata, no labelling was detected. In the outer part of the inner nuclear layer, putative horizontal cells were labelled for mGluR5. More proximal in this layer, corresponding to the position of bipolar cell somata, there was strong labelling for mGluR6. A small number of bipolar cells were also labelled for mGluR5 and mGluR7. In situ hybridization with isolated cells showed that mGluR6 was expressed by rod bipolar cells. Subsets of amacrine cells, with cell bodies along the border between the inner nuclear layer and the inner plexiform layer, were positive for mGluR1, 2, 4 and 7, suggesting considerable heterogeneity of these receptors among amacrine cells. None of the seven metabotropic receptor mRNAs was expressed in isolated Müller glial cells. In the ganglion cell layer, virtually every ganglion cell and displaced amacrine cell was labelled for mGluR1 and mGluR4. Some cells in this layer (approximately 20% of the total), most likely both ganglion cells and displaced amacrine cells, were also labelled for mGluR2 and mGluR7. These findings suggest that metabotropic glutamate receptors are considerably more widespread among neurons in the retina than indicated by previous physiological and pharmacological investigations.

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Section: Amacrine Cellsmentioning

confidence: 98%

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

Hartveit

Brandstätter

Enz

et al. 1995

Eur J of Neuroscience

103

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“…For example, mouse models of retinal degeneration ( rd1−/− and rd10−/− ) have decreased DOPAC and DOPAC/DA levels throughout life and increased susceptibility to form deprivation myopia [47]. Since DA is released via ON pathway stimulation [135], mutations in the ON pathway would decrease retinal DA levels. Such is the case in Nyx wt/wt mice which have reduced DA and DOPAC levels and increased susceptibility to myopia [48].…”

Section: Retinal Neurons/pathways and Refractive Development In Mumentioning

confidence: 99%

Molecular and Biochemical Aspects of the Retina on Refraction

Chakraborty¹,

Pardue²

2015

Progress in Molecular Biology and Translational Science

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Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.

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“…These synapses apparently drive the ϳ40% of DA cells that demonstrate ON-transient responses. ON pathway input to DA cells is likely a general feature of vertebrate retinas, because L-AP-4 blocks light-induced dopamine release in monkey and frog retinas (Boatright et al, 1994;Boelen et al, 1998).…”

Section: Da Cell Spontaneous Activity and Regulationmentioning

confidence: 99%

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Zhang¹,

Zhou²,

McMahon³

2007

J. Neurosci.

113

149

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Inhibition of endogenous dopamine release in amphibian retina byl-2-amino-4-phosphonobutyric acid (l-AP4) andtrans-2-aminocyclopentane-1,3-dicar☐ylate (ACPD)

Cited by 27 publications

References 15 publications

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

Expression of the mRNA of Seven Metabotropic Glutamate Receptors (mGluR1 to 7) in the Rat Retina. An In Situ Hybridization Study on Tissue Sections and Isolated Cells

Molecular and Biochemical Aspects of the Retina on Refraction

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

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