“…The importance of antiviral drugs is increasingly apparent owing to PRRSV persistence in pigs. There are a growing number of antiviral agents reported interfering with PRRSV attachment or/and entry, including antimicrobial peptides protegrin-1 ( Guo et al, 2015 ), cecropin P1 ( Guo et al, 2014a ), cecropin D ( Liu et al, 2015 ), lavaspidic acid AB ( Yang et al, 2013 ), glycyrrhizin ( Duan et al, 2015 ), tetrahydroaltersolanol C ( Zhang et al, 2016 ), curcumin ( Du et al, 2017 ), griffithsin ( Li et al, 2018a ), iota-carrageenan ( Guo et al, 2019b ), polyethylenimine ( Wang et al, 2019b ), 25-hydroxycholesterol ( in vitro and in vivo ) ( Ke et al, 2017 ; Song et al, 2017 , 2019 ; Dong et al, 2018 ) and rottlerin ( in vitro and in vivo ) ( Kang et al, 2021 ). Chinese herbal medicines also contain antiviral molecules to block PRRSV attachment and entry ( Bello-Onaghise et al, 2020 ).…”