Abstract:Background and Purpose Chronic obstructive pulmonary diseases (COPD) are
age-related, airflow-obstruction diseases mostly caused by cigarette
smoke. However, the relationship between COPD and lung cellular
senescence is still not fully understood. Here, we investigated how E3
ligase Pellino-1 mediated COPD and lung cellular senescence.
Experimental Approach We used western blot, qPCR and co-IP assays to
analyze the correlation of Pellino-1 and P21 in cells with or without
silencing Pellino-1. Then we used flow… Show more
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