Inhibition of cytokine production by vitamin D3 deficiency

Kankova, M.; Luini, Walter; Pedrazzoni, M.; Riganti, Franca; Sironi, Marina; Bottazzi, Barbara; Mantovani, Alberto; Vecchi, Amedeo F. De

doi:10.1016/0192-0561(91)90315-x

Cited by 43 publications

(48 citation statements)

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“…This deficiency resulted, however, in an impressively disturbed inflammatory behaviour of the NOD macrophages, with lower respiratory burst capacity and a disturbed cytokine profile with increased IL15 mRNA expression and extremely low IL1 and IL6 expression. This low expression of IL1 and IL6 is in agreement with previous reports in rachitic animals [28]. Abnormalities in macrophages have been implicated in the pathogenesis of Type 1 diabetes, with these cells being one of the first to be present in insulitis [29,30].…”

Section: Discussionsupporting

confidence: 93%

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

et al. 2004

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Aims/hypothesis. 1,25-dihydroxyvitamin D 3 , the active form of vitamin D, prevents Type 1 diabetes in non-obese diabetic (NOD) mice. Epidemiological data show a threefold increase in human Type 1 diabetes when vitamin D deficiency was present in the first months of life. To evaluate whether a similar dietary deficiency affects diabetes incidence in NOD mice, we generated NOD mice with vitamin D deficiency in early life. Methods. Breeding pairs of NOD mice, as well as their offspring (test mice), were kept in surroundings devoid of ultraviolet light and were fed a vitamin Ddepleted diet for 100 days. Mice were followed for 250 days. Results. At 250 days, 35% (12/35) male and 66% (22/33) female vitamin D-deficient mice were diabetic compared to 15% (6/40, p=0.05) and 45% (13/29, p<0.01) of the control mice. At 100 days no difference in insulitis was seen, but more vitamin D-deficient mice were glucose intolerant. Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15). Thymus and lymph nodes of vitamin D-deficient mice contained less CD4 + CD62L + cells. Conclusion/interpretation. Vitamin D status increases the expression of Type 1 diabetes in NOD mice. Our data in NOD mice, as well as human epidemiological data, point to the importance of preventing vitamin D deficiency in early childhood. Controlling this dietary factor could be an easy and safe way to reduce the incidence of Type 1 diabetes in subjects who are genetically at risk. [Diabetologia (2004)

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Section: Discussionsupporting

confidence: 93%

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

et al. 2004

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“…It reminds other mechanisms than PTH have role at this pathology. In recent studies showed that vitamin D has an important role at innate and adaptive immunity, besides calcium metabolism [20,21]. The results of our study showed that non-survivors had statistically significant low baseline vitamin D concentration than survivors.…”

Section: A) B)supporting

confidence: 69%

“…Vitamin D and PTH data at day 5 were not available in 9 patients because of death before day 5. 28 days ICU mortality rate was 51.2% (21). Median age of study population was 67 years and the median Apachee II score was 28 .…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies showed that vitamin D has a pivot role in innate and adaptive immunity besides effects on calcium homeostasis [19]. In contrast to its inhibitory role in adaptive immunity, vitamin D is a potent activator of innate immune system and a natural defense mechanism to microorganisms [20,21]. Evidences accumulated in literature in last five years suggest that significant proportion of critically ill patients have low vitamin D status [22,23] and this situation is associated with increased ICU mortality [24].…”

Section: Introductionmentioning

confidence: 99%

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Sequential vitamin D and parathyroid hormone measurement in patients with septic shock: Could they be prognostic marker in septic shock

Yeter

Aktepe

Topeli

2018

j-ebr

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A B S T R A C T Aim:Hypocalcemia is a common clinical problem in critically-ill patients and it is associated with increased morbidity and mortality. The aim of this study was to investigate serum calcium, vitamin D and parathyroid hormone (PTH) levels in surviving and non-surviving septic shock patients. Method: Patients with septic shock criteria and who were older than 18 years of age were included, whereas patients with diseases influencing calcium homeostasis were excluded. Demographic and laboratory parameters were recorded prospectively. Results: 41 patients, 20 of which were male were included in the study. The median (min-max) age of study population was 67 (19-88) years. Frequency of hypocalcemia in the study population was 29.2% and 68.2% according to corrected calcium and ionized calcium, respectively. On the day septic shock was diagnosed (day 1), median vitamin D levels of survivors and non-survivors were 8.7 ng/ml (4.3-30.4) and 5.3 ng/ml (1.0-21.7), respectively (p=0.05). On the same day, median PTH levels of survivors and non-survivors were 94 ng/L (16.9-1746) and 49 ng/L (6.6-339), respectively (p=0.042). Although vitamin D levels were suppressed and PTH levels were elevated in non-survivors at day 5, this change was not statistically significant (p=0.19 and p=0.187). Conclusion: Hypocalcemia is frequent in septic shock patients, whereas vitamin D levels were low and PTH levels were high in the diagnosis day. These results suggest that vitamin D is suppressed by septic shock at non-surviving patients during course of septic shock. Parathyroid hormone may be a marker for worse outcome in critically ill patients.

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“…Next to the correlation between vitamin D status and the prevalence of autoimmune diseases, vitamin D deficiency has also been associated with an increased susceptibility to infections such as tuberculosis 56 . A more detailed analysis of the immune system of vitamin D-deficient mice revealed defects in macrophage functions, such as chemotaxis, phagocytosis and pro-inflammatory cytokine production, all indispensable for antimicrobial activity 49,57 . In addition, a disturbed delayed-type hypersensitivity response has been reported in mice lacking vitamin D 58 .…”

Section: 25-dihydroxyvitamin D 3 and The Immune Systemmentioning

confidence: 99%

Vitamin D₃and the immune system: maintaining the balance in health and disease

et al. 2007

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Inhibition of cytokine production by vitamin D3 deficiency

Cited by 43 publications

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Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Sequential vitamin D and parathyroid hormone measurement in patients with septic shock: Could they be prognostic marker in septic shock

Vitamin D₃and the immune system: maintaining the balance in health and disease

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Inhibition of cytokine production by vitamin D3 deficiency

Cited by 43 publications

References 0 publications

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Sequential vitamin D and parathyroid hormone measurement in patients with septic shock: Could they be prognostic marker in septic shock

Vitamin D3and the immune system: maintaining the balance in health and disease

Contact Info

Product

Resources

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Vitamin D₃and the immune system: maintaining the balance in health and disease