Inhibition of cytokine-induced IκB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice

Nam, Kwanghee; Kim, Jihyun; Hong, Ji‐Man; Choi, Jaehoon; Mar, Woonchon; Cho, Myung‐Haing; Kim, Young‐Myeong; Oh, Sei‐Ryang; Lee, Hyeong‐Kyu; Nam, Ki-Hoan; Oh, Goo Taeg

doi:10.1016/j.atherosclerosis.2004.11.022

Cited by 38 publications

(35 citation statements)

References 29 publications

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“…In mice fed with HCD supplemented tilianin, however, the NOx level was significantly decreased by about 50% ( Figure 1C). In correspondence to the lowered NOx level, the lesions induced by HCD were decreased by the treatment of tilianin, similar to our previous study (Nam et al, 2005) ( Figure 1D). …”

Section: Effects Of Tilianin On Plasma Levels Of No and Lesion Formationsupporting

confidence: 91%

“…In our previous study, we have reported that tilianin, a major component of Agastache rugosa (Labiatae) significantly inhibits the tumor necrotic factor-(TNF-)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVEC) as its potential antiatherogenic mechanism (Hong et al, 2001;Nam et al, 2005). However, it has not been determined the effect of tilianin on NO production.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Nam

Choi²,

Seo³

et al. 2006

Exp Mol Med

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We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal macrophages of Ldlr-/-mice. High cholesterol diet induced nitric oxide production in the plasma of Ldlr-/-mice. Tilianin reduced the level of nitric oxide (NO) in plasma from Ldlr-/-mice induced by the high cholesterol diet. Tilianin also inhibited the NO production from the primary culture of peritoneal macrophages treated with lipopolysaccharide. The inhibition of NO production was caused by the suppression of inducible nitric oxide synthase (iNOS) gene expression in peritoneal macrophages isolated from Ldlr-/-mice. Moreover, tilianin inhibited the transcriptional activation of iNOS promoter that has NF-κB binding element. Thus, these results provide the first evidence that tilianin inhibit iNOS expression and production of NO and may act as a potential anti-inflammatory agent.

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Section: Effects Of Tilianin On Plasma Levels Of No and Lesion Formationsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Nam

Choi²,

Seo³

et al. 2006

Exp Mol Med

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“…Tilianin is chosen because it is a flavonoid compound that has attracted much attention for its anti-atherogenic, antihypertensive, and anticonvulsive properties. It was originally isolated from Dracocephalum moldavica L. (DML) (16) and Agastache rugosa (17). It can be used for the treatment of hypertension (18).…”

Section: Introductionmentioning

confidence: 99%

“…It can be used for the treatment of hypertension (18). Additionally, tilianin has been found to reduce atherosclerotic lesion formation through the inhibition of cytokine-induced IκB kinase activation (17). Acacetin, the flavone aglycone of tilianin, can be found in many more plants including propolis (19,20), Robinia pseudoacacia (21), and DML (16).…”

Section: Introductionmentioning

confidence: 99%

Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

Dai

Zhu

Luo

et al. 2015

AAPS J

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Abstract. Triple recycling (i.e., enterohepatic, enteric and local recycling) plays a central role in governing the disposition of phenolics such as flavonoids, resulting in low systemic bioavailability but higher gut bioavailability and longer than expected apparent half-life. The present study aims to investigate the coexistence of these recycling schemes using model bioactive flavonoid tilianin and a foursite perfused rat intestinal model in the presence or absence of a lactase phlorizin hydrolase (LPH) inhibitor gluconolactone and/or a glucuronidase inhibitor saccharolactone. The result showed that tilianin could be metabolized into tilianin glucuronide, acacetin, and acacetin glucuronide, which are excreted into the bile and luminal perfusate (highest in the duodenum and lowest in the colon). Gluconolactone (20 mM) significantly reduced the absorption of tilianin and the enteric and biliary excretion of acacetin glucuronide. Saccharolactone (0.1 mM) alone or in combination of gluconolactone also remarkably reduced the biliary and intestinal excretion of acacetin glucuronide. Acacetin glucuronides from bile or perfusate were rapidly hydrolyzed by bacterial β-glucuronidases to acacetin, enabling enterohepatic and enteric recycling. Moreover, saccharolactone-sensitive tilianin disposition and glucuronide deconjugation, which was more active in the small intestine than the colon, points to the small intestinal origin of the deconjugation enzyme and supports the presence of local recycling scheme. In conclusion, our studies have demonstrated triple recycling of a bioactive phenolic (i.e., a model flavonoid), and this recycling may have an impact on the site and duration of polyphenols pharmacokinetics in vivo.

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“…Recent studies have reported that anti-inflammatory compounds prevent the progression of atherosclerosis without altering the blood lipid profiles in hyper lipidemic mice [83,84], indicating that anti-inflammatory compounds may be used as therapeutic agents for the treatment of inflammatory diseases. The ginseng berry has been shown to suppress reactive oxygen species production [85,86], NF-κB activation [19] and inflammatory gene expression [87] in vitro and in vivo.…”

Section: Anti-inflammation and Anti-oxidative Activitymentioning

confidence: 99%

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Seo¹

2016

JARB

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Journal of Advanced Research in Biotechnology Open Access Review Article Introduction: Ginseng and the Ginseng berryGinseng (Panax ginseng) is a popular herbal medicine that has been used in Asia for 5,000 years [1]. Ginseng is classified as fresh, white, or red ginseng, depending on the processing method. As a traditional herb, red ginseng is known as an adaptogen that restores and improves normal well-being. The use of this herbal plant has been widespread throughout the world because of its therapeutic effects. The well-known biochemical and pharmacological effects include anti-cancer [2], anti-fatigue [3], and anti-diabetic effects [4], along with promoting the synthesis of DNA, RNA and proteins [5]. The herb is used as a tea, an extract, or raw directly from powdered root [6]. The representative bioactive compounds are widely considered to begin senosides, which are ginseng-specific saponins [7]. Currently, more than 100 naturally occurring saponins of various types and products of enzymatic conversion have been isolated from the roots, stems, leaves, flowers, berries, and seeds of ginseng. The different parts of ginseng contain distinct ginsenoside profiles, and thus, different parts probably possess different pharmacological effects [8].Recently, many health reports have recommended an increase in fruit intake as part of a healthy dietary pattern [9,10]. These reports allow for various forms of fruit, including fresh, frozen, and dried, as well as juices, and recommend fruits such as oranges, apples, bananas, grapes, raisins, and berries. Whereas berries are known as a good source of potassium or fiber, recent studies suggest that berry fruits are a rich source of many phytochemicals that have a broad spectrum of bioactivity and a positive impact on general health. Several berry fruits, including blackberries, blueberries, cranberries, raspberries, and strawberries, have recently received attention as a result of their effects in vitro and their associations with lowered risks for some chronic diseases, which were found in recent observational research [11,12]. As a perennial herb, ginseng develops flowers and fruits that bloom in its third and fourth year. Unlike the widely used ginseng root, the ginseng berry is preserved for planting and has not been used by general populations. A recent study reported that the ginseng leaf and berry have higher levels of ginsenosides than ginseng root, and their pharmacological activities have also been reported [13]. In this review, we will summarize the research on the role of dietary ginseng berries in delaying aging, as well as evidence suggesting positive biological effects to prevent age-related diseases. Ginseng Berry Bioactive Content and CompositionThe bioactive components of ginseng are triterpene glycosides or saponins, which are commonly regarded as ginsenosides. AbstractA recent effort in the development of new medications and immune modulatory agents is to search for candidates among natural products because they have relatively low toxicities in clinica...

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Inhibition of cytokine-induced IκB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice

Cited by 38 publications

References 29 publications

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

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