Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways

Dai, Jianping; Gu, Liming; Su, Yun; Wang, Qianwen; Zhao, Ying; Chen, Xiao-Xua; Deng, Huixiong; Li, Weizhong; Wang, Gefei; Li, Kangsheng

doi:10.1016/j.intimp.2017.11.009

Cited by 200 publications

(177 citation statements)

References 47 publications

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“…In our present study, the results demonstrate the involvement of PRR signaling-related pathways including NOD-like receptors, Toll-like receptors ( Figure 5) and RIG-I like receptors signaling ( Supplementary Table S3) pathways in the biological functions of VCG Plus, as well as the IFNs (IFNG, IFNB1 in Table 1). Previous studies have revealed that CC significantly stimulated the production of IFN-β (IFNB1) in mice infected with influenza A virus (IAV), resulting in the increased survival rate and improvement of pulmonary histopathological changes [66]. Similarly, VC improved the production of IFN α/β (IFNA1/B1), activated anti-viral immune responses and remarkably increased the survival rate of VC-depleted mice infected with IAV [67,68].…”

Section: Discussionmentioning

confidence: 99%

“…VC decreases IL-4, IL-6 and IL-8 level via inhibition of NF-κB signaling pathway in concanavalin A-induced liver injury mice [90]. Many studies have shown that CC presents anti-inflammatory function via NF-κB signaling [91,92], PI3K/AKT signaling [93], MAPK signaling [66] and TLRs signaling pathways [94]. In addition, GA alleviated inflammation via NF-kB and p38/ERK pathways in the reduction in multiple cytokines, including IL-6, TNF-α, IL-8, IL-1β and HMGB1 [95].…”

Section: Discussionmentioning

confidence: 99%

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A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

116

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Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

116

View full text Add to dashboard Cite

show abstract

“…Therefore, exploring new antiinfluenza drugs is urgently needed (Suzuki et al 2003). Curcumin, a coloring agent and spice commonly used in food (Goel et al 2007), inhibits the replication of IAV in vitro and in vivo (Kannan and Kolandaivel 2017;Dai et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Due to its versatile pharmacological properties, including anti-inflammatory, anti-tumor, and anti-oxidant activities (Maheshwari et al 2006;Anand et al 2007;Goel et al 2007), curcumin has attracted considerable interest. In particular, curcumin is reported to have anti-influenza virus activity by interfering with the cellular signaling pathways (such as Toll-like receptor2/4, p38/c-Jun N-terminal kinase, mitogen-activated protein kinase, and nuclear factor-κB pathways) or with proteins required for influenza virus replication (Dai et al 2018;Richart et al 2018). Ou et al (2013) reported that the presence of the double bonds in the central seven-carbon chain enhances the curcumin-dependent anti-IAV activity and curcumin might interfere with IAV entry by its interaction with the receptor binding region of hemagglutinin.…”

Section: Introductionmentioning

confidence: 99%

3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase

Lai

Liao

et al. 2020

Arch. Pharm. Res.

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“…Clinical and laboratory data of COVID-19 showed evidence of in ammatory and immune injury, con rming that cytokine storms could be a crucial factor linked to the severity and mortality of COVID-19. MAPK3 and MAPK1, belong to serine/threonine protein kinase family, and the activation of MAPK promotes virus infection and in ammatory response [53][54][55]. REL/NF-κB family of transcription factors plays a central role in initiation and resolution of in ammatory responses [56,57].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanisms of Lian Hua Qing Wen Capsule against COVID-19 by Network Pharmacology and Molecular Docking Approach

Chen¹,

Qu²,

Tan³

et al. 2020

Preprint

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Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) disease has led to a wide-spread global pandemic. There is no specific antiviral drug proven effective for the treatment of patients with COVID-19 at present. Combination of western and traditional Chinese medicine (TCM) is recommended, and Lian Hua Qing Wen (LHQW) capsule is a basic prescription and widely used to treat COVID-19 in China. However, the mechanisms of LHQW capsule treating COVID-19 are not clear. The aim of the study is to explore the mechanisms of LHQW capsule treating COVID-19 based on network pharmacy and molecular docking approach. Methods The active compounds and targets of LHQW capsule were obtained from traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). COVID-19 related target genes were obtained from GeneCards database and OMIM database. Protein–protein interaction (PPI) networks of LHQW capsule targets and COVID-19-related genes were visualized and merged to identify the candidate targets for LHQW capsule treating COVID-19. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were also performed. The hub genes involved in the gene-related pathways were screened and their corresponding compounds were used for in vitro validation of molecular docking predictions.Results A total of 185 active compounds of LHQW capsule were screened out, and 263 targets were predicted. Third hundred and fifty-two COVID-19 related target genes were obtained from GeneCards database and OMIM database. GO functional enrichment analysis showed that the biological processes of LHQW capsule treating COVID-19 were closely linked with the regulation of inflammation, immunity, cytokines production, vascular permeability, oxidative stress and apoptosis. KEGG enrichment analysis revealed that the pathways of LHQW capsule treating COVID-19 were significantly enriched in AGE−RAGE signaling pathway in diabetic complications, Kaposi sarcoma−associated herpesvirus infection, TNF, IL−17, and Toll−like receptor (TLR) signaling pathway. The hub targets genes in the gene-related pathways analysis of LHQW capsule treating COVID-19 included MAPK1, MAPK3, RELA, IL-6 and CASP8, which closely associated with inflammation, cytokines storm and apoptosis. Finally, molecular docking showed that top 5 compounds of LHQW capsule also had good binding activities to the important targets in COVID-19.Conclusions The mechanisms of LHQW capsule treating COVID-19 may involve in inhibiting inflammatory response, cytokine storm and virus infection, and regulating immune reactions, apoptosis and endothelial barrier.

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Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways

Cited by 200 publications

References 47 publications

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase

Exploring the Mechanisms of Lian Hua Qing Wen Capsule against COVID-19 by Network Pharmacology and Molecular Docking Approach

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