Inhibition of coxsackie, echo and hepatitis A virus infection by polyelectrolytes

Seganti, L; Mastromarino, Paola; Petruzziello, R.; Gabrieli, R; Divizia, Maria Teresa; Panà, Augusto; Orsi, N

doi:10.1016/0166-3542(91)90151-g

Cited by 1 publication

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“…The current study showed that (91.7%) of leukemia patients were positive for BKPyV antigenuria as compared to (65%) positive cases in control (p=<0.001) Table (1), and there is significantly higher number of positive cases for BKPyV antigen in urine in ALL patients who were under the age of 9 years (p= 0.001) Table (2) and who were males ALL patients (p=0.001) Table (3). While BKPyV antigen in urine positivity had no significant effect on leukocyte levels of the patients (p=0.9) Table (4), there was no significant correlation between BKPyV positivity and frequency of relapses (p=0.366) Table (5)…”

Section: Resultsmentioning

confidence: 47%

“…The results of this study showed significantly higher number of positive cases for BKPyV antigen in urine in ALL patients who were under the age of 9 years (p value = 0.001) table (2) and whom where males (p value = 0.001) table (3). As it has been established that urinary excretion of BKPyV is more in children under the age of 9 years, this is supported by the results of a study of "age-related Urinary excretion of BK Polyomavirus by nonimmunocompromised individuals" that in the 0to 9-year-old group, the urinary detection rate for the BKPyV was relatively high (24%) but declined in the 10-to 19-and 20-to 29-yearold groups [39].…”

Section: Discussionmentioning

confidence: 62%

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Detection of Bk Polyomavirus Antigen in Patients with Acute Lymphoblastic Leukemia

H Ali ,,

Satti ,,

H Ali ,

et al. 2023

djm

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Background: BK polyomavirus that is acquired in early childhood as BKPyV is near ubiquitous in adults with a seroprevalence of >80%, it has been found as the main cause of hemorrhagic cystitis in hematopoietic stem cell transplantation patients, due to immunosuppression regimen that lead to the activation of the virus from the latency status and lead to increased viral shedding in urine (viuria). Objective: To investigate the frequency of BK Polyomavirus antigen excretion in urine of children with acute lymphoblastic leukemia with and without chemotherapy and compare it with normal controls. Patients and Methods: A case-control study conducted from December 2021 to May 2022 in Baghdad, Iraq on leukemia patients of Central Pediatrics Hospital (Al-Eskan ). Urine samples and urine sediment smears were collected from 60 acute lymphoblastic leukemia patients. And compared with 60 apparently healthy age and sex-matched children, BK polyomavirus antigen in urine was detected using Enzyme-linked Immunosorbent Assay and urine cytology were Pap stained for the detection of decoy cells (DCs). Results: Positive BKPyV antigen in urine was seen in 55 (91.7%) of Acute lymphoblastic leukemia patients and 39 (65.0%) in controls (p=<0.001) and all the patients were decoy negative. There was no significant effect of the positivity of antigenuria on neither leukocytes level nor on the occurance of relapse in leukemia patients. Conclusion: The very high frequency of BKPyV in the urine signifies the importance of reactivation of this virus in ALL patients with and without chemotherapy.

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