Abstract:Male weanling Fischer rats were injected ip once daily with either 12.5 mgkg body weight cupric chloride or 2 mVkg body weight saline for up to 70 days. As the hepatic cytosolic copper increased in copper-treated rats, copper bound to proteins of different molecular weights; this was determined by gel filtration chromatography. Hepatic cytosolic copper from rats treated with cupric chloride for 14 days eluted in 3 peaks. These included a 150,000+ dalton peak, a 29,000 dalton peak and an 11,000-12,800 dalton pe… Show more
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