“…Therapeutic targeting of microglia has been demonstrated to be effective in some circumstances. Administration of CSF1R inhibitors ablates microglia from the CNS and is beneficial in limiting damage and promoting recovery in a wide variety of animal models with severe neurodegeneration or tissue damage (Acharya et al, 2016;Asai et al, 2015;Dagher et al, 2015;Feng et al, 2016Feng et al, , 2017Janova et al, 2018;Klein et al, 2015;Lee, Shi, Fan, West, & Zhang, 2018;Li et al, 2017;Nissen, Thompson, West, & Tsirka, 2018;Qu et al, 2017;Rice et al, 2015;Sosna et al, 2018;Spangenberg et al, 2016;Walter & Crews, 2017). However, microglia ablation has not always been shown to be beneficial and is severely damaging in other neurodegenerative mouse models Spiller et al, 2018;Szalay et al, 2016;Wheeler, Sariol, Meyerholz, & Perlman, 2018;Yang et al, 2018).…”