Inhibition of cold-induced vasoconstriction with ketanserin

Hechtman, Daniel H.; Jageneau, A

doi:10.1016/0026-2862(85)90037-8

Cited by 10 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observation that an oceandwelling mammal such as the Steller sea lion transports high levels of serotonin inside platelets is fascinating in this context. Serotonin is known to change skin perfusion [64] by contracting cutaneous arterioles in response to cooling [65,66] and dilating cutaneous vessels in response to heat [8]. Human platelets change shape and take up serotonin when exposed to low temperature [46], which appears to contradict the notion that serotonin exerts its vasoactive properties by interacting with endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…The mutant mice displayed a significant drop in peripheral serotonin causing progressively abnormal cardiac activity and bleeding [32]. In homeotherms, such as mammals and birds, the blood facilitates initial rewarming of peripheral regions and a subsequent decrease in cutaneous perfusion to reduce heat loss when the environmental temperature is lower than the core temperature [33]. Serotonin plays a major role in this process.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Circulating serotonin in vertebrates

Maurer‐Spurej

2005

CMLS, Cell. Mol. Life Sci.

View full text Add to dashboard Cite

The role of circulating serotonin is unclear and whether or not serotonin is present in the blood of non-mammalian species is not known. This study provides the first evidence for the presence of serotonin in thrombocytes of birds and three reptilian species, the endothermic leatherback sea turtle, the green sea turtle and the partially endothermic American alligator. Thrombocytes from a fresh water turtle, American bullfrog, Yellowfin tuna, and Chinook salmon did not contain serotonin. Serotonin is a vasoactive substance that regulates skin blood flow, a major mechanism for endothermic body temperature regulation, which could explain why circulating serotonin is present in warm-blooded species. The temperature sensitivity of human blood platelets with concomitant changes in serotonin content further supports a link between circulating serotonin and thermoregulation. Phylogenetic comparison of the presence of circulating serotonin indicated an evolutionary divergence within reptilian species that might coincide with the emergence of endothermy.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Circulating serotonin in vertebrates

Maurer‐Spurej

2005

CMLS, Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…'9 It is still uncertain whether cold-induced vasoconstriction is also modified by prostacyclin2°'2' or serotonin22 and by their antagonists thromboxane A220 or ketan-. 21,23 serin. 21,23 We have shown that intravenous PG12 significantly improved total skin blood flow as measured by laser Doppler in healthy subjects.…”

Section: Discussionmentioning

confidence: 98%

“…21,23 serin. 21,23 We have shown that intravenous PG12 significantly improved total skin blood flow as measured by laser Doppler in healthy subjects. The marked improvement in total finger skin blood flow has to be ascribed to vasodilation in the arteriovenous shunt vessels because capillary skin perfusion, as measured by Tcpo2l was only slightly affected.…”

Section: Discussionmentioning

confidence: 98%

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Wollersheim

Thien

1988

Angiology

View full text Add to dashboard Cite

The selective hemodynamic effects of an intravenous infusion of prostacyclin on skin and on forearm blood flow during increasing doses up to 6 ng.kg.-1 min.-1 were evaluated in 12 healthy volunteers. The highest dose raised total skin blood flow (p = 0.0001) as measured by laser Doppler with a concomitant rise in finger skin temperature (p = 0.02). Capillary perfusion as measured by transcutaneous oxygen monitoring remained relatively unaffected (p = 0.25). Cold-induced vasoconstriction and the recovery thereafter were not influenced. Diastolic blood pressure tended to decrease (p = 0.06), but there was no change in systolic blood pressure, forearm blood flow, and calculated forearm vascular resistance. The authors conclude that prostacyclin may have dissimilar vasoactive potencies in different vascular beds as shown by a pronounced increase in total skin blood flow, owing to vasodilation of shunt vessels, simultaneously with an insignificant change in nutritional skin blood flow and forearm muscle blood flow.

show abstract

“…Besides, virtually inactive doses of 5-HT enhance the reduction of forearm flow induced by intra-arterial infusion of noradrenaline [122]. Cold induced vasoconstriction in volunteers [123], and the vascular symptoms of patients suffering from Raynaud's phenomenon can be corrected by ketanserin treatment [124][125][126].…”

Section: Clinical Evidencementioning

confidence: 99%

Platelet-vessel wall interactions: Implication of 5-hydroxytryptamine. A review

Clerck¹,

Nueten

Reneman³

1984

Agents and Actions

View full text Add to dashboard Cite

The evidence for an impact of platelet-derived 5-hydroxytryptamine (5-HT) on local tissue perfusion is reviewed. By interacting with 5-HT2 serotonergic receptors, 5-HT, directly or through amplification, activates platelets, endothelial and vascular smooth muscle cells producing platelet aggregation, vascular permeability increase and large vessel constriction. Pharmacodissection in experimental animals with selective serotonergic 5-HT2 receptor antagonists, e.g. ketanserin, shows that 5-HT largely contributes to the platelet-mediated increase in vascular permeability, to platelet-vessel wall interaction during hemostasis, to cardiopulmonary dysfunction provoked by thromboembolism and to the platelet-mediated inhibition of peripheral collateral circulation. Clinical results obtained with ketanserin further substantiate an involvement of platelet-derived 5-HT in the pathogenesis of impaired tissue perfusion in some cardiovascular conditions.

show abstract

Inhibition of cold-induced vasoconstriction with ketanserin

Cited by 10 publications

References 12 publications

Circulating serotonin in vertebrates

Circulating serotonin in vertebrates

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Platelet-vessel wall interactions: Implication of 5-hydroxytryptamine. A review

Contact Info

Product

Resources

About