Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat

Choi, Sin Young; Kee, Hae Jin; Jin, Li; Ryu, Yuhee; Sun, Simei; Kim, Gwi Ran; Cho, Jeong Gwan

doi:10.1016/j.biopha.2018.02.071

Cited by 45 publications

(27 citation statements)

References 38 publications

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“…GA reduced nuclear and cytoplasmatic DNA methyltransferases in H1299 cells [37]. GA was also found to be a potent inhibitor of HDAC8 and class IIa/b HDAC activity [38].In addition, GA demonstrated anti-invasive effects in human nasopharyngeal carcinoma cells NPC-BM1 through the inhibition of p38 MAPK signaling pathway, this was due to suppressed transcription of MMP-1 by down-regulation of Ets1 and c-Jun, c-fos of the AP-1 [39]. In case of AGS cells, GA up-regulated of RhoB and the down-regulated Akt/small GTPase signals and NF-κB activity inhibited cell migration [40].…”

Section: Gallic Acidmentioning

confidence: 92%

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Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.

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Section: Gallic Acidmentioning

confidence: 92%

“…Moreover, we emphasize important role of phenolics as epigenetic regulators. GA was demonstrated to be a potent inhibitor of DNMT as well as HDAC [38]. Furthermore, an ability of CA to attenuate cancer stem cells-like properties was mediated by microRNA-148a [59].…”

Section: Conclusion and Future Aspectsmentioning

confidence: 99%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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“…Spatial learning and memory dysfunction [135] Chemotherapy-induced neuropathic pain [136] Protection of granulosa cells against oxidative stress [137] Cadmium-mediated carcinogenesis [138] Oxidative stress in cultured adult cardiomyocytes [139] Protective effects of glucosinolate hydrolysis products in neurodegenerative diseases [140] Clearance of Amyloid-β and Tau protein in a mouse model of AD [141] Experimental diabetic peripheral neuropathy [142] Joint inflammation in a murine adjuvant-induced mono-arthritis [143] Protection against cognitive impairment in AD-like lesions in diabetes [144] Anti-inflammatory effect of SFN on human THP-1 macrophages in a murine AD model [145] Inhibition of oxidative stress/inflammation improves cardiac function in a Rabbit Model of Chronic Heart Failure [146] Inhibition of class IIa histone deacetylase activity [147] Apoptosis via microtubule disruption in cancer [148] Inhibition of LPS-Induced Inflammation/cytotoxicity/oxidative microglial stress [149] Down-regulation of MAPK/NF-κB signaling in LPS-activated BV-2 microglia [150] Inhibition of oxidative stress in an in vitro model of age-related macular degeneration [151] Modification of Histone H3, unpacking of chromatin, to prime defence [128] Modulation of oxidative stress and inflammation in rats with toxic hepatitis [152] Modulation of oxidative damage in lead exposed rat hippocampus [153] Table 5. Cont.…”

Section: Medical Conditions Treated With Sulphoraphanementioning

confidence: 99%

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

Melrose

2019

Biomedicines

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This study reviewed aspects of the biology of two members of the glucosinolate family, namely sinigrin and glucoraphanin and their anti-tumour and antimicrobial properties. Sinigrin and glucoraphanin are converted by the β-sulphoglucosidase myrosinase or the gut microbiota into their bioactive forms, allyl isothiocyanate (AITC) and sulphoraphanin (SFN) which constitute part of a sophisticated defence system plants developed over several hundred million years of evolution to protect them from parasitic attack from aphids, ticks, bacteria or nematodes. Delivery of these components from consumption of cruciferous vegetables rich in the glucosinolates also delivers many other members of the glucosinolate family so the dietary AITCs and SFN do not act in isolation. In vitro experiments with purified AITC and SFN have demonstrated their therapeutic utility as antimicrobials against a range of clinically important bacteria and fungi. AITC and SFN are as potent as Vancomycin in the treatment of bacteria listed by the World Health Organisation as antibiotic-resistant “priority pathogens” and also act as anti-cancer agents through the induction of phase II antioxidant enzymes which inactivate potential carcinogens. Glucosinolates may be useful in the treatment of biofilms formed on medical implants and catheters by problematic pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus and are potent antimicrobials against a range of clinically important bacteria and fungi. The glucosinolates have also been applied in the prevention of bacterial and fungal spoilage of food products in advanced atmospheric packaging technology which improves the shelf-life of these products.

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“…Inhibition of class IIa histone deacetylase activity [140] Apoptosis via microtubule disruption in cancer [141] Inhibition of LPS-Induced Inflammation/cytotoxicity/oxidative microglial stress [142] Down-regulation of MAPK/NF-κB signaling in LPS-activated BV-2 microglia [143] Epigenetic modification of Nrf2 signalling in a model of AD [144] Inhibition of oxidative stress in an In-vitro model of age-related macular degeneration [145] Prevention of angiotensin II-induced cardiomyopathy by activation of Nrf2 and Akt/GSK-3ß/Fyn pathway.…”

Section: The Diverse Areas Of Application Of Sulphoraphane (Sfn) In Bmentioning

confidence: 99%

The Glucosinolates, A Sulphur Glucoside Family of Mustard Phytochemicals With Diverse Biomedical Application

Melrose¹

2019

Preprint

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This study reviewed aspects of the biology of two members of the glucosinolate family, namely sinigrin and glucoraphanin and their potential biomedical therapeutic and industrial applications. Sinigrin and glucoraphanin are converted by the -sulphoglucosidase myrosinase or the gut microbiota into their bioactive forms, allyl isothiocyanate (AITC) and sulphoraphanin (SFN) which constitute part of a sophisticated defence mechanism plants have developed over several hundred million years of evolution to protect them from parasitic attack from aphids, ticks and nematodes.These compounds display biological activities in a number of mammalian physiological processes and potential biotherapeutic application. Glucosinolates may be useful in bio-fumigation and treatment of biofilms which occur on plant equipment and medical implants formed by problematic pathogenic bacteria such as Pseudomonas aeruginosa. AITC and SFN display similar antibiotic activity as Vancomycin in the treatment of bacteria listed by the World Health Organization as antibiotic-resistant "priority pathogens".AITC and SFN also display bioactivity in cancer chemoprevention through the induction of phase II antioxidant enzymes which inactivate potential carcinogens. The glucosinolates have found application in the prevention of bacterial and fungal spoilage of food substances during processing and in advanced food packaging formats which improve the shelf-life of food products.

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Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat

Cited by 45 publications

References 38 publications

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

The Glucosinolates, A Sulphur Glucoside Family of Mustard Phytochemicals With Diverse Biomedical Application

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