Inhibition of cholinesterase and amyloid‐<i>β</i> aggregation by resveratrol oligomers from <i>Vitis amurensis</i>

Jang, Moon Hee; Piao, Xiang Lan; Kim, Jong Moon; Kwon, Sung Won; Park, Jeong Hill

doi:10.1002/ptr.2406

Cited by 139 publications

(87 citation statements)

References 28 publications

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“…The search for new lead compounds for AD and oligomer-oriented therapeutics includes considerable effort focusing on natural products, including constituents of red wine [111][112][113][114][115][116], olive oil [117], and green tea [53,115,118,119]. Wu et al [120] carried out a study of EGb 761, a standardized extract of Ginkgo biloba, that has received attention because of its reputed value in enhancing memory [121][122][123][124].…”

Section: Wu Et Al (2006) Amyloid β-Induced Pathological Behaviors Armentioning

confidence: 99%

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

Klein

2012

JAD

120

105

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The oligomer hypothesis for Alzheimer's disease (AD)was introduced in 1998. It was based on evidence that oligomers could exist free of amyloid fibrils, that fibril-free oligomer solutions rapidly inhibited long term potentiation, and that oligomers ultimately caused a highly selective nerve cell death. Fibrils no longer were the only toxins made by amyloid-β (Aβ), and likely not the most important ones. Oligomers provided a new basis for instigating AD. Since introduction of the hypothesis, more than 1,500 articles on oligomers have been published. Articles for this review were selected for contributions to oligomer theory at three different levels. The first set demonstrated new aspects of oligomer pathobiology in cell models, showing that exposure of neurons to oligomers is sufficient to cause key features of AD neuropathology. The second set confirmed the relationship between oligomers and salient AD neuropathology in animal models, consistent with other in vivo studies that overall have substantiated cell-based discoveries. The third set developed strategies for therapeutic targeting of oligomers, introducing both small molecule and antibody-based approaches. These and related findings from many groups have helped establish oligomers as central to the mechanism of AD pathogenesis. Comprising a ligand-based attack on specific synapses, the action of toxic oligomers gives a molecular basis to account for key features of AD neuropathology and to explain why early disease targets memory. Although there still is no effective treatment for AD, insights over the past five years raise hopes that new approaches targeting Aβ oligomers could finally bring disease-modifying therapeutics.

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Section: Wu Et Al (2006) Amyloid β-Induced Pathological Behaviors Armentioning

confidence: 99%

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

Klein

2012

JAD

120

105

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“…This result is consistent with previous research. [ 43,44 ] The chloride and sodium concentrations in the serum of these two group mice were similar (Figure S5, Supporting Information). Our results suggest that the buckwheat diet did not affect the absorption of salt in mice, nor did it affect the concentration of sodium in feces.…”

Section: Discussionmentioning

confidence: 84%

High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet

Xiao

et al. 2020

Molecular Nutrition Food Res

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Scope: A high-salt diet is a cause of gastritis, but the associated mechanism remains unclear. Recent studies have shown that gastric flora is associated with a variety of stomach diseases, but it is not known whether gastric flora is involved in gastritis induced by a high-salt diet. Methods and results: Gastritis is successfully induced in C57BL/6 mice fed a high-salt diet (salt: 5% NaCl) for four weeks. Through 16S rRNA gene sequencing, the composition of the stomach microbiota of mice fed normal and high-salt diets are compared, the results of which show that the high-salt diet induces significant changes in the gastric flora. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) is used to predict the function of the microbiota in the stomach of mice, and the results indicate that a high-salt diet leads to a decrease in the ability of the gastric microbiota to metabolize polysaccharides and vitamins. A buckwheat diet is used to treat gastritis. The results show gastritis induced by the high-salt diet is significantly alleviated, and the dysbiosis in the stomach also improved. Conclusion: Buckwheat diet may be one of the ways to prevent and treat gastritis caused by a high-salt diet.

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“…It was used as a natural plant compound in traditional Chinese and Japanese medicine) [7,8,9]. Although interest in this compound was initially almost exclusively focused on its antioxidant properties, it has since been reported to possess a wide range of other biological and pharmacological activities including anti-inflammatory, anti-mutagenic, and anti-carcinogenic effects [10,11,12,13,14]. …”

Section: Resveratrol As An Antioxidant Drugmentioning

confidence: 99%

“…In this context, attention has turned to resveratrol (RESV), a naturally-occurring polyphenolic compound with strong antioxidant properties and abundantly found as a component of red wine [7,8,9]. Research has described several beneficial properties of this compound, including anti-carcinogenic, anti-ageing, neuroprotective, analgesic, anti-diabetic and anti-obesity effects [9,10,11,12,13,14,15,16,17,18]. The aim of the present review is to discuss the potential beneficial effects of RESV in the treatment of neurological disorders, not only as concerns its antioxidant properties, but also through the activation of sirtuin 1 [18,19,20,21,22,23,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases

et al. 2009

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The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.

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Inhibition of cholinesterase and amyloid‐β aggregation by resveratrol oligomers from Vitis amurensis

Cited by 139 publications

References 28 publications

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet

Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases

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