Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation

Nakai, Kuniharu; Tazuma, Susumu; Nishioka, Tomoji; Chayama, Kazuaki

doi:10.1016/s1388-1981(03)00060-x

Cited by 18 publications

(18 citation statements)

References 25 publications

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“…Kinetics of cholesterol crystallization in bile is modulated by protein as well as non‐protein components. These have been the subject of more than a decade of study, and glycoproteins and bilirubin, not nutritional substances, are listed as potential effector substances …”

Section: Gallstone and Lipid Metabolismmentioning

confidence: 98%

Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction

Tazuma

Kanno

Sugiyama

et al. 2013

J of Gastro and Hepatol

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Nutritional factors play a key role in the pathogenesis of biliary diseases such as gallstones and pancreaticobiliary maljunction. Gallstones are primarily classified into cholesterol stone and pigment stone according to the major composition. Cholesterol gallstone formation is very likely based upon supersaturated bile formation, and pigment stones are formed in bile rich in bilirubin. Thus, defects of hepatic metabolism of lipids and organic anions lead to biliary stones. Here, the recent understanding of cholesterol gallstone pathogenesis is elaborated. On the other hand, there is another important link of biliary lipid degradation to serious biliary disease, namely pancreaticobiliary maljunction. Lysophosphatidylcholine (lysoPC), a derivative of phosphatidylcholine hydrolysis by phospholipase A2, is a highly abundant bioactive lipid mediator present in circulation as well as in bile. Increases in bile of lysoPC and phospholipase A2 have been reported in pancreaticobiliary maljunction and considered to be the major risk factor for biliary tract cancers. Further, oxidized fatty acids have been established as a potent ligand for G2A, a member of G protein-coupled receptor family that mediates a diverse array of biological processes including cell growth and apoptosis. Thus, both of lysoPC and free fatty acids are supposed to play an important role through G2A in biliary inflammation and carcinogenesis of pancreaticobiliary maljunction. Taken together, nutritional factors, especially lipid compounds, are seemingly crucial in the pathogenesis of biliary diseases, and such a causal relationship is reviewed by mainly authors' previous publications.

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Section: Gallstone and Lipid Metabolismmentioning

confidence: 98%

Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction

Tazuma

Kanno

Sugiyama

et al. 2013

J of Gastro and Hepatol

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mentioning

confidence: 99%

“…A s a natural bile acid synthesized in liver, cholic acid (CA) possesses unique facial amphiphilicity and multiple functional group structures, which make it a significant building block for preparing biocompatible materials. 1 Due to the structural rigidity and unusual structure of hydrophobic and hydrophilic regions, CA exhibits self-assembly property and can form distinctive supramolecular architectures with potential biological and medical applications. Depending on the type of CA-based polymers and self-assembly conditions, massive selfassembly aggregates with fascinating morphologies such as micellar structures, 2−6 gel fibrils, 7,8 tubules, 9,10 wrinkled structures, 11 and helical structures 12,13 have been reported in recent years.…”

mentioning

confidence: 99%

Optically Active Helical Polyacetylene Self-Assembled into Chiral Micelles Used As Nanoreactor for Helix-Sense-Selective Polymerization

Zhao

Deng

2016

ACS Macro Lett.

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Chiral micelles have been drawing ever-increasing attention because of their potentials in mimicking the unique stereochemical effects of enzymes. This article reports on the first success in preparing chiral micelles through self-assembly of helical polyacetylene bearing cholic acid pendants. The micelles were further used as chiral nanoreactor, in which achiral acetylenic monomer smoothly underwent helix-sense-selective polymerization (HSSP). The HSSPs directly established optically active core/shell nanoparticles whose shell and core both were constructed by helical polymers. The shells (or micelles) provided a protective effect for the preferably induced one-handed helical polymer chains in the cores. The present work provides insights into the self-assembly of chiral helical polymers, and also provides a powerful strategy for constructing novel chiral polymer nanoarchitectures.

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“…Secretory cells produce cervical mucus. Cervical mucus contains cholesterol, concentration is highest before estrus [10], cholesterol forms crystal structures [11]. Cervical mucus contain mucins which are high molecular weight glycoproteins forming complex mesh-type structures.…”

Section: Discussionmentioning

confidence: 99%

Fluorescence Spectrum and Decay Measurement for Hsil vs Normal Cytology Differentiation in Liquid Pap Smear Supernatant

Vaitkuvienė¹,

Gėgžna²,

Juodkazis³

et al. 2009

AIP Conference Proceedings

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Cervical smear material contains endo and exocervical cells, mucus and inflammative, immune cells in cases of pathology. Just not destroyed keratinocytes lay on the glass for microscopy. Liquid cytology supernatant apart other diagnostics could be used for photodiagnostic. The spectroscopic parameters suitable for Normal and HSIL cytology groups supernatant differentiation are demonstrated.The dried liquid PAP supernatant fractions -sediment and liquid were investigated. Excitation and emission matrices (EEM), supernatant fluorescence decay measured under 280 nm diode short pulse excitation and fluorescence spectroscopy by excitation with 355 nm laser light were analyzed.The differences between Normal and HSIL groups were statistically proven in the certain spectral regions. Fluorescence decay peculiarities show spectral regions consisting of few fluorophores. Obtained results on fluorescence differences in Normal and HSIL groups' supernatant shows the potency of photodiagnosis application in cervical screening.

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Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation

Cited by 18 publications

References 25 publications

Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction

Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction

Optically Active Helical Polyacetylene Self-Assembled into Chiral Micelles Used As Nanoreactor for Helix-Sense-Selective Polymerization

Fluorescence Spectrum and Decay Measurement for Hsil vs Normal Cytology Differentiation in Liquid Pap Smear Supernatant

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