Inhibition of chitin synthesis by benzoyl-phenylurea insecticides, III. Similarity in action in Pieris brassicae (L.) with Polyoxin D

Gijswijt, M.J.; Deul, D.H.; Jong, B.J. de

doi:10.1016/0048-3575(79)90098-1

Cited by 56 publications

(26 citation statements)

References 6 publications

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“…asoensis. 10 ) Although growth inhibition was apparent between molts, the toxic effects of the ingested plumbagin became evident only during the molt. Possibly, the abortive molt (due to inhibition of ecdysis, Table I and Figs.…”

mentioning

confidence: 99%

An Insect Ecdysis Inhibitor from the African Medicinal Plant,Plumbago capensis(Plumbaginaceae); a Naturally Occurring Chitin Synthetase Inhibitor

Kubo¹,

Uchida²,

Klocke³

1983

Agricultural and Biological Chemistry

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mentioning

confidence: 99%

An Insect Ecdysis Inhibitor from the African Medicinal Plant,Plumbago capensis(Plumbaginaceae); a Naturally Occurring Chitin Synthetase Inhibitor

Kubo¹,

Uchida²,

Klocke³

1983

Agricultural and Biological Chemistry

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“…Gijswijt et al (1979) demonstrated that polyoxin-D was toxic when injected into fifth-instar larvae of Pieris brassicae, but it was not effective when fed to those larvae (Verloop and Ferrell 1977). However, polyoxin-D is much less potent as a larvicide against L. cuprina than is diflubenzuron, even though both compounds are similarly effective as inhibitors of chitin synthesis in isolated larval integuments.…”

Section: Discussionmentioning

confidence: 99%

Effects of Several Larvicidal Compounds on Chitin Biosynthesis by Isolated Larval Integuments of the Sheep Blowfly Lucilia cuprina

Turnbull¹,

Howells²

1982

Aust. Jnl. Of Bio. Sci.

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Isolated whole integuments from L. cuprina larvae rapidly incorporate radioactivity from both N-acetyl[I-'4C]glucosamine and [1-'4C]glucosamine into alkali-insoluble material, a reaction which does not require preincubation of the tissue with /i-ecdysone. The labelled product was degraded to N-acetylglucosamine during digestion with chitinase, establishing that it consists mainly of chitin. Incorporation was inhibited by polyoxin-D (Iso, 6 x 10-7 M) and diflubenzuron (Iso, 7 x 10-7M) but was not inhibited to any marked extent by isoprothiolane, Vetrazin or a-methyl-DOPA. The effectiveness of diflubenzuron as an inhibitor of chitin synthesis in this system (Iso, 7 x 10-7 M) correlates well with its potency as a larvicide (LDso, 2·1 x 10-6 M), providing additional support for the proposal that this compound kills larvae by interfering with chitin deposition in the cuticle. Polyoxin-D was much more effective as an inhibitor of chitin synthesis (Iso, 6 x 10-7 M) than as a larvicide (LDso, 2·0x 10-5 M). It was established that the final intermediate of chitin biosynthesis (UDP-N-acetylglucosamine) was formed in the isolated integuments in the presence of diflubenzuron and polyoxin-D. It seems likely therefore that both compounds interfere with the final polymerization step of the chitin biosynthesis pathway.

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“…Mortality induced by DFB in insects and crustaceans is attributed to the inability of the individual to cast its exuvium during the moulting process (Christiansen et al 1978;Gijswijt et al 1979;Gulka et al 1980;Weiss et al 1987). Little concern exists over its effects on organisms such as birds, mammals and fishes because of its specific mode of action (Granett 1987;Mauchamp and Perrineau 1987).…”

Section: Introductionmentioning

confidence: 99%

Effect of diflubenzuron on the maturation and reproductive success of the copepod Eurytemora affinis

et al. 1996

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: The insect growth regulator diflubenzuron (DFB) may have substantial effects on non-target organisms, especially crustaceans. By targeting the moulting process, DFB would be expected to elicit the most obvious effects on subadult crustaceans which moult frequently. Previous studies in this laboratory have demonstrated acute and chronic effects of DFB on survival and development of nauplii of the estuarine copepod Eurytemora affinis at water concentrations of less than 1 p.p.b. The present study examines the effects on maturation to adulthood and brood production. Effects on brood production were observed at 0.8 p.p.b. DFB in individuals exposed only during the copepodite stages. Significant effects on production of nauplii were documented only in the early exposure to 0.93 p.p.b. DFB. Inability of post-moult copepodites to completely cast exuviae also was documented in the exposed treatments. At salinities of 2, 10 and 15 p.p.t., survival from naupliar to adult stages was significantly reduced at 0.84 p.p.b. and none survived to adulthood at 1.7 p.p.b. These results suggest that DFB has substantial effects on survival and development of E. affinis at a water concentration of less than 1 p.p.b. DFB concentrations exceeding this concentration have been reported from Chesapeake Bay surface waters although there is no current evidence of potentially toxic concentrations overlapping with the known distribution of E. affinis in the bay.

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Inhibition of chitin synthesis by benzoyl-phenylurea insecticides, III. Similarity in action in Pieris brassicae (L.) with Polyoxin D

Cited by 56 publications

References 6 publications

An Insect Ecdysis Inhibitor from the African Medicinal Plant,Plumbago capensis(Plumbaginaceae); a Naturally Occurring Chitin Synthetase Inhibitor

An Insect Ecdysis Inhibitor from the African Medicinal Plant,Plumbago capensis(Plumbaginaceae); a Naturally Occurring Chitin Synthetase Inhibitor

Effects of Several Larvicidal Compounds on Chitin Biosynthesis by Isolated Larval Integuments of the Sheep Blowfly Lucilia cuprina

Effect of diflubenzuron on the maturation and reproductive success of the copepod Eurytemora affinis

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