“…Although cyclic nucleotides are known to modulate leukocyte activation processes, their role in cell locomotion is still controversial. In human isolated neutrophils and mononuclear cells, increase of cGMP levels has been shown to either stimulate ( Kaplan et al , 1989 ; Belenky et al , 1993a ,1993b; Wanikiat et al , 1997 ) or inhibit ( Schröder et al , 1990 ; Bath et al , 1991 ; Moilanen et al , 1993 ; Kosonen et al , 1999 ; Conran et al , 2001 ) the in vitro chemotaxis and adhesion. On the other hand, the soluble guanylyl cyclase inhibitor 1 H ‐[1,2,4] oxidiazolo[4,3‐ α ] quinoxalin‐1‐one (ODQ) has been clearly shown to reduce concentration‐dependently N ‐formyl‐ L ‐methionyl‐ L ‐leucyl‐phenylalanine (fMLP)‐induced eosinophil chemotaxis, suggesting a key role for cGMP in these cells ( Zanardo et al , 1997 ; Thomazzi et al , 2001 ).…”