Inhibition of carcinogenesis by tea: The evidence from experimental studies

Dreosti, Ivor E.; Wargovich, Michael J.; Yang, Chung S.

doi:10.1080/10408399709527801

Cited by 192 publications

(101 citation statements)

References 30 publications

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“…Some of the results have been reviewed previously [1][2][3][4][5][6][7][8]. Table 1 summarizes the results of 120 studies published since the year 1991.…”

Section: Inhibition Of Tumorigenesis In Animal Models and Possible Mementioning

confidence: 99%

Inhibition of carcinogenesis by tea constituents

Lǚ

Lambert

et al. 2007

Seminars in Cancer Biology

130

104

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The possible cancer preventive activity of tea has received much attention in recent years. The inhibitory activities of tea and tea constituents against carcinogenesis at different organ sites have been demonstrated in many animal models. The effect of tea consumption on human cancers, however, remains inconclusive. The mechanisms of action of tea polyphenols, especially EGCG, the most abundant and active catechin, have been extensively investigated. Most of the studies, however, were based on cell culture systems, and these mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer. Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents.

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“…Some of the results have been reviewed previously [1][2][3][4][5][6][7][8]. Table 1 summarizes the results of 120 studies published since the year 1991.…”

Section: Inhibition Of Tumorigenesis In Animal Models and Possible Mementioning

confidence: 99%

Inhibition of carcinogenesis by tea constituents

Lǚ

Lambert

et al. 2007

Seminars in Cancer Biology

130

104

View full text Add to dashboard Cite

show abstract

“…Green tea polyphenols have physiologic activities such as anticancer effects (Hara et al, 1989;Isemura et al, 1993;Muramatsu, 1994;Ito and Sasaki, 1995;Suganuma and Okabe, 1996;Dreosti et al, 1997;Imai et al, 1997), antioxidative activity (Kawase et al, 2000;Yokozawa et al, 2000), antibacterial effects (Sakanaka et al, 1989;Mabe et al, 1999;Amarowicz et al, 2000), antioxidative activity against low-density lipoprotein cholesterol (Rice-Evans et al, 1996;Miura et al, 2000), and reduction of blood cholesterol level (Muramatsu et al, 1986;Imai and Nakachi, 1995), body weight, body fat (Hase et al, 2001;Nagao et al, 2001;Tsuchida et al, 2002;Kajimoto et al, 2005), blood glucose level (Hara and Honda, 1990;Honda and Hara, 1993;Matsumoto et al, 1993) and suppression of postprandial triglyceride elevation (Unno et al, 2005). Therefore, it is expected that green tea polyphenols have preventive effects against lifestyle-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities

et al. 2007

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Objective: We examined whether green tea-extract powder supplementation improves glucose abnormality. Methods: The study was conducted for volunteers who resided in eastern communities of Shizuoka Prefecture and who had fasting blood glucose levels of X6.1 mmol/l or nonfasting blood glucose levels of X7.8 mmol/l in a recent health check-up. Sixty subjects aged 32-73 years (49 males and 11 females) participated in the trial. The Early intervention group consumed a packet of green tea-extract powder containing 544 mg polyphenols (456 mg catechins) daily for the first 2 months and then entered the 2-month nonintervention period. The Later intervention group was observed for the first 2 months and then consumed green tea-extract powder as described above for the subsequent 2 months. Using the two-period crossover design, we analyzed the changes in fasting hemoglobin A1c level and other biomarkers in blood samples collected at baseline, 2 months and 4 months. Results: A significant reduction in hemoglobin A1c level and a borderline significant reduction in diastolic blood pressure were associated with the intervention. The intervention caused no significant changes in weight, body mass index, body fat, systolic blood pressure, fasting serum glucose level, homeostasis model assessment index, serum lipid level or hypersensitive C-reactive protein.Conclusion: Daily supplementary intake of green tea-extract powder lowered the hemoglobin A1c level in individuals with borderline diabetes.

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“…The antitumor effects (-) EGCG were discovered from various cancerous cell lines, animal models, and clinical studies. [11][12][13] Several studies have demonstrated that (-) EGCG plays a pivotal role in prevention of the proliferation of cervical cancer linked with induction of apoptosis and inhibition of telomerase, respectively. [14][15][16] Several in vitro studies have reported that pure (-) EGCG led to inhibition the growth of oral squamous carcinoma cells and oral epithelial cells.…”

Section: Reported Pharmacological Activities Antineoplasticmentioning

confidence: 99%

Untitled

Khurana

2017

IJGP

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Green tea leaves (Camellia sinensis, Family Theaceae) have been consumed in the form of beverage since long, but their widespread health benefits have been discovered relatively recently. Epigallocatechin gallate (EGCG) is a polyphenol found abundantly in these leaves. It is a potent antioxidant which helps greatly in combating the oxidative stress generated in the body during various physiological processes. Oxidative stress plays a great role in the development of various chronic diseases such as heart diseases, cancer, and neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. Oxidative stress is also involved in the process of aging. The oxygen radical absorbance capacity assay conducted by the US Department of Agriculture clearly signifies that brewed green tea is a potent antioxidant in comparison to majority of antioxidant rich foods, such as brewed black tea, raw kiwi, lemon juice, and extra virgin olive oil. EGCG has shown promising results in the therapy of various diseases and disorders such as cancers, fatty liver disease, HIV infection, hypertension, Type-II diabetes mellitus, obesity, and neurodegenerative diseases. Some recent studies have revealed novel actions of EGCG, such as interaction with proteins and phospholipids in the plasma membrane. This review presents a comprehensive outlook on the reported pharmacological activities of EGCG along with its green extraction method, pharmacokinetic and toxicity profiles. The data have been collected by several research and review papers obtained from various journal resources including PubMed Central and Elsevier.

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Inhibition of carcinogenesis by tea: The evidence from experimental studies

Cited by 192 publications

References 30 publications

Inhibition of carcinogenesis by tea constituents

Inhibition of carcinogenesis by tea constituents

Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities

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