Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test.

Parker, A.C.; Preston, Tom; Heaf, D P; Kitteringham, Neil R.; Choonara, Imti

doi:10.1111/j.1365-2125.1994.tb04399.x

Cited by 30 publications

(19 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ciprofloxacin inhibits CYP1A2-mediated metabolism of caffeine Avoid concurrent use; monitor for caffeine toxicity [135] Caffeine/adenosine The effects of adenosine may be blunted by caffeine Caffeine antagonizes the increase in blood flow mediated by adenosine for antagonism at the receptors of adenosine Avoid concurrent use; evaluate whether to increase the doses of adenosine or to use alternative agents [136] MAO: Monoamine oxidase; SSRIs: Selective serotonin re-uptake inhibitors.…”

Section: Concentrations and Effects Of Caffeine May Be Increasedmentioning

confidence: 99%

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Ferrari

Baraldi

Sternieri

2015

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

In spite of progress in migraine treatment, the prevalence of chronic headaches and MOH has not changed in the course of time. Today, a large number of migraine patients have turned to numerous expert physicians and experienced all sorts of prophylactic treatments without decisive benefits. Their condition seems to have crystallized even more as chronic and intractable. This means that to prevent chronification and MOH, we need more effective drugs and better strategies to use them. In particular, we must detect disease biomarkers and predictive factors for drug response that allow for personalized treatment when migraine is still episodic and make analgesic overuse pointless.

show abstract

Section: Concentrations and Effects Of Caffeine May Be Increasedmentioning

confidence: 99%

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Ferrari

Baraldi

Sternieri

2015

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

show abstract

“…We have previously used the Shreeve method [6], which assumes a constant value of 300 mmol CO 2 =h m 2 body surface [8][9][10][11] to estimate CO 2 production rate during 13 C breath tests. Alternatively, BMR can be estimated using the Schofield equations [12], which are generally agreed to give a more accurate estimate in children [13].…”

Section: Introductionmentioning

confidence: 99%

Is there an advantage in normalising the results of theHelicobacter Pylori[¹³C]Urea breath test for CO₂production rate in children?

Slater

Preston

Weaver

2004

Isotopes in Environmental and Health Studies

View full text Add to dashboard Cite

The urea breath test (UBT) is a non-invasive diagnostic test to detect the presence of Helicobacter pylori in the stomach, and is the simplest way to confirm eradication after treatment. The test is based on the capacity of H. pylori to secrete the enzyme urease, which hydrolyses urea to ammonia and carbon dioxide. The aim of this study was to determine whether there is an advantage in expressing the results of UBTs in terms of urea hydrolysis rate (UHR), rather than breath 13C enrichment alone. Retrospective analysis of data collected between 1995 and 2002 from 260 patients undergoing UBTs was performed. The cut-offs for positive tests using breath 30-minute enrichment (E30), UHR calculated using VCO2 estimated from height and weight (H/WT) and VCO2 estimated from weight only were determined using two-graph receiver operator characteristic (TG-ROC) analysis. The cut-off points were 3.5/1000 or 38.7 ppm 13C excess, 7.04 micromol/h and 7.08 micromol/h, respectively. There was no advantage in expressing the results as UHR (theta0, Theta-zero, where sensitivity = specificity = 0.97 (UHR H/WT), 0.98 (UHR WT) and 1.00 (E30)) rather than breath 13CO2 enrichment alone. Differences in the extent of H. pylori colonisation and urease activity are more important than variation in VCO2 in determining breath 13CO2 enrichment in the UBT.

show abstract

“…13 C-breath tests are useful noninvasive methods to measure, among other parameters, gastrointestinal function and to monitor pharmacological and nutritional interventions (Parker et al, 1994(Parker et al, , 1997aAmarri and Weaver, 1995;Amarri et al, 1997;Ling et al, 2000). 13 C-breath tests are particularly attractive for use in children because they are noninvasive, and pose no radiation hazard.…”

Section: Introductionmentioning

confidence: 99%

Comparison of accuracy and precision of heart rate calibration methods to estimate total carbon dioxide production during 13C-breath tests

2005

Self Cite

View full text Add to dashboard Cite

Background:13 C-breath tests are noninvasive tools to measure gastrointestinal function and nutritional interventions. Calculation of percentage dose recovered of 13 C in exhaled breath requires knowledge of CO 2 production rate (VCO 2 ). A resting value is usually assumed, but this can underestimate VCO 2 because subjects are unlikely to remain at rest during tests that last for many hours. There is a need for a method to estimate nonresting VCO 2 during 13 C-breath tests. Objective: To calibrate a heart rate monitor to continually estimate VCO 2 during 13 C-breath tests. Design: Proof of concept study. Subjects: Eight healthy adults, 10 healthy children and six children with cystic fibrosis. Methods: Heart rate and VCO 2 were measured simultaneously at resting and nonresting levels. A new calibration method (smoothing heart rate and fitting a sigmoid function) was compared with published methods. A [ 13 C]acetate breath test was used to demonstrate the range of physical activity during breath tests. Results: The new calibration method was more accurate than existing methods (mean bias À0.0002%, 95% confidence interval (CI) À0.0007, 0.0003% of the mean measured VCO 2 ). Smoothing heart rate gave a more precise estimate of VCO 2 and a more accurate estimate of resting energy expenditure (mean bias À0.09, 95% CI À0.22, 0.05 mmol CO 2 min À1 m À2 body surface area) than using raw data (mean bias À0.21, 95% CI À0.38, À0.04 mmol CO 2 min À1 m À2 body surface area). Physical activity level ranged from 1.0 to 2.5 in children, and 1.0 to 1.5 in adults. Conclusion: Use of smoothed HR with a sigmoid function provides an accurate method of estimating nonresting VCO 2 during 13 C-breath tests.

show abstract

Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test.

Cited by 30 publications

References 11 publications

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Is there an advantage in normalising the results of theHelicobacter Pylori[¹³C]Urea breath test for CO₂production rate in children?

Comparison of accuracy and precision of heart rate calibration methods to estimate total carbon dioxide production during 13C-breath tests

Contact Info

Product

Resources

About

Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test.

Cited by 30 publications

References 11 publications

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Is there an advantage in normalising the results of theHelicobacter Pylori[13C]Urea breath test for CO2production rate in children?

Comparison of accuracy and precision of heart rate calibration methods to estimate total carbon dioxide production during 13C-breath tests

Contact Info

Product

Resources

About

Is there an advantage in normalising the results of theHelicobacter Pylori[¹³C]Urea breath test for CO₂production rate in children?