1999
DOI: 10.1016/s0162-3109(99)00042-9
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Inhibition of Ca2+ influx by pentoxifylline in NR8383 alveolar macrophages

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Cited by 11 publications
(5 citation statements)
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“…NCS 613) were potent and selective PDE4 inhibitors (18). The aim of the present study was to evaluate the effect of new more potent PDE4 inhibitors belonging to the same chemical series on TNF-␣ as well as on interleukin (IL)-1␤, IL-6 and IL-8 production by lipopolysaccharide (LPS) activated peripheral blood mononuclear cells (PBMCs) from healthy subjects, and to compare them to two selective PDE4 inhibitors, RP 73401 (Piclamilast) (19,20) and Denbufylline (21), as well as a non-selective PDE inhibitor, Pentoxifylline (22).…”
mentioning
confidence: 99%
“…NCS 613) were potent and selective PDE4 inhibitors (18). The aim of the present study was to evaluate the effect of new more potent PDE4 inhibitors belonging to the same chemical series on TNF-␣ as well as on interleukin (IL)-1␤, IL-6 and IL-8 production by lipopolysaccharide (LPS) activated peripheral blood mononuclear cells (PBMCs) from healthy subjects, and to compare them to two selective PDE4 inhibitors, RP 73401 (Piclamilast) (19,20) and Denbufylline (21), as well as a non-selective PDE inhibitor, Pentoxifylline (22).…”
mentioning
confidence: 99%
“…[Ca 2ϩ ] i was measured using the Ca 2ϩ sensitive fluorescent probe fura-2 as previously described [Zhang et al, 1997;Mörk et al, 1998a;Sun et al, 1999]. NR8383 AMs were loaded with fura-2 by incubation with 2 M fura-2/AM for 20 min at 37°C.…”
Section: Measurement Of [Ca 2؉ ] Imentioning
confidence: 99%
“…Excitation wavelengths used were 340 and 380 nm and emission wavelength was 505 nm. Calibration of [Ca 2ϩ ] i was performed for each measurement trace as previously described [Zhang et al, 1997;Mörk et al, 1998a;Sun et al, 1999]. Fluorescence ratios of the 340/380 nm excitation and 505 nm emission were converted to [Ca 2ϩ ] i according to Grynkiewicz et al [1985] using 224 nM as the K d of fura-2 at 37°C for Ca 2ϩ .…”
Section: Measurement Of [Ca 2؉ ] Imentioning
confidence: 99%
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“…In Xenopus oocytes, acute stimulation of PKC with a phorbol ester initially enhanced thapsigarginevoked Ca 2ϩ entry (via SOC), as indicated by the endogenous Ca 2ϩ -dependent Clcurrent(40). In NR8383 alveolar macrophages, stimulation of PKC corresponded to activation of Ca 2ϩ influx(41). In whole-cell patch-clamp experiments with RBL-2H3 cells, Parekh and Penner (42) demonstrated that inward Ca 2ϩ current through SOC was accelerated by PMA and prevented by inhibitors of PKC.This study is seemingly in conflict with at least two studies that have demonstrated that PKC mediates SOC inhibition.…”
mentioning
confidence: 97%