Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption

Chakkalakal, Dennis A.; Novak, Jerzy R.; Fritz, Edward D.; Mollner, Teresa J.; McVicker, Daniel L.; Garvin, Kevin L.; McGuire, Michael H.; Donohue, Terrence M.

doi:10.1016/j.alcohol.2005.08.001

Cited by 63 publications

(41 citation statements)

References 39 publications

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“…Pro [32] NSAID use at admission Pro [13,27] Con [17,35] NSAID use at discharge Pro [13,27] Con [17,35] Opioid use at admission Pro [12] Opioid use at discharge Pro [12] Human immunodeficiency virus Pro [24] Con [20] Hepatitis C None Diabetes Pro [13,21,27] ASA score Pro [16] Smoking status Pro [13,21,31,36] Con [29,35] Alcohol use Pro [10,13,21] AO classification Pro [30] Con [2,22] ISS score Pro [30] TRISS score Pro [30] ICU days None * Pro articles support a correlation between nonunion and the variable; Con articles show that the variable has no correlation with nonunion; GSW = gunshot wound; NSAID = nonsteroidal anti-inflammatory drug; ASA = American Society of Anesthesiologists; AO = Arbeitsgemeinschaft für Osteosynthesefragen; ISS = Injury Severity Score; TRISS = Trauma and Injury Severity Score; ICU = intensive care unit.…”

Section: Compartment Syndromementioning

confidence: 99%

Will My Tibial Fracture Heal? Predicting Nonunion at the Time of Definitive Fixation Based on Commonly Available Variables

O’Halloran

Coale

Costales

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background Accurate prediction of tibial nonunions has eluded researchers. Reliably predicting tibial nonunions at the time of fixation could change management strategies and stimulate further research. Questions/purposes We asked (1) whether data from medical records, fracture characteristics, and radiographs obtained at the time of fixation would identify features predictive of tibial fracture nonunion; and (2) whether this information could be used to create a model to assess the chance of nonunion at the time of intramedullary (IM) nail fixation of the tibia. Methods We retrospectively reviewed all tibial shaft fractures treated at our center from 2007 to 2014. We conducted a literature review and collected data on 35 factors theorized to contribute to delayed bone healing. Patients were followed to fracture healing or surgery for nonunion. Patients with planned prophylactic nonunion surgery were excluded because their nonunions were anticipated and our focus was on unanticipated nonunions. Our cohort consisted of 382 patients treated with IM nails for tibial shaft fractures (nonunion, 56; healed, 326). Bivariate and multivariate regression techniques and stepwise modeling approaches examined the relationship between variables available at definitive fixation. Factors were included in our model if they were identified as having a modest to large effect size (odds ratio [ 2) at the p \ 0.05 level. Results A multiple variable logistic regression model was developed, including seven factors (p \ 0.05; odds ratio [ 2.0). With these factors, we created the Nonunion Risk Determination (NURD) score. The NURD score assigns 5 points for flaps, 4 points for compartment syndrome, 3 points for chronic condition(s), 2 points for open fractures, 1 point for male gender, and 1 point per grade of American Society of Anesthesiologists Physical Status and percent cortical contact. One point each is subtracted for spiral fractures and for low-energy injuries, which were found to be predictive of union. A NURD score of 0 to 5 had a 2% chance of nonunion; 6 to 8, 22%; 9 to 11, 42%; and[12, 61%. Conclusions The proposed nonunion prediction model (NURDS) seems to have potential to allow clinicians to better determine which patients have a higher risk of nonunion. Future work should be directed at prospectively validating and enhancing this model. Level of Evidence Level III, diagnostic study.

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Section: Compartment Syndromementioning

confidence: 99%

Will My Tibial Fracture Heal? Predicting Nonunion at the Time of Definitive Fixation Based on Commonly Available Variables

O’Halloran

Coale

Costales

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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“…Recent studies concluded that heavy alcohol consumption inhibits bone neo-formation in fracture sites [20,21].…”

Section: Discussionmentioning

confidence: 99%

http://medcraveonline.com/JOENTR/volume_issues?issueId=1343&volumeId=415

P¹,

ini²,

Lourenço³

et al. 2017

JOENTR

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Alcohol is widely consumed in the world. Excessive alcohol intake causes alterations in bone tissues. The objective of this paper is to review the effects of chronic alcohol use in bone microarchitecture and the mechanisms by which this abuse may decrease bone mineral density. Furthermore, in the second part of the review, it's related the different techniques to induce bone loss in rats by alcoholization.Objectives: The aim of this paper is to review in the recent literature the negative effects of chronic alcohol intake in bone health and the mechanisms responsible for that. It's also review the different techniques available for experimental alcohol-induced osteopenia in rodents. Methods:Pubmed database was systematically searched to obtain all the eligible papers, published in English language, covering the period between 1997 and 2014. The literature search combined several key words including: bone, alcoholism, cortical bone, ethanol, bone density, rat and animal models.Results: A total of thirty-eight articles were selected in Pubmed database, considering the key words aforementioned. In the review, it is included twentynine articles published in English, in the period between 1997 and 2014.

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“…Além disso, estes animais apresentam afinidade para o consumo voluntário de solução alcoólica (Callaci et al, 2004;Chakkalakal et al, 2005;Rocha, 2005).…”

Section: Parâmetros Bioquímicosunclassified

“…O procedimento cirúrgico de indução da deficiência hormonal foi precedido, com sucesso, por diversos trabalhos (Turner, 2001;Callaci et al, 2006;Blouin et al, 2007;Senra, 2009), bem como o modelo com dieta alcoólica por consumo voluntário também foi desenvolvido com sucesso em estudos anteriores (Chakkalakal, 2005;Chakkalakal et al, 2005;Rocha, 2005;Alonso, 2009;Deco, 2009). …”

Section: Parâmetros Bioquímicosunclassified

“…A exposição crônica a altas concentrações de etanol pode acarretar atraso no crescimento e desenvolvimento ósseo (Keiver et al, 2005;Lauing et al, 2008), redução da remodelação e da resistência óssea (Turner, 2000;Chakkalakal et al, 2005), e piora na qualidade do reparo ósseo (Chakkalakal, 2005;Deco, 2009). Por causa desta relação entre etanol e osso, a ruptura do equilíbrio mineral ósseo pode refletir nos parâmetros bioquímicos de cálcio e fosfato ósseo e elevar o risco de osteoporose (Keiver et al, 2005).…”

Section: Parâmetros Bioquímicosunclassified

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Repercussões minerais ósseas no alcoolismo crônico associado à deficiência hormonal em ratos

Lodi¹

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Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption

Cited by 63 publications

References 39 publications

Will My Tibial Fracture Heal? Predicting Nonunion at the Time of Definitive Fixation Based on Commonly Available Variables

Will My Tibial Fracture Heal? Predicting Nonunion at the Time of Definitive Fixation Based on Commonly Available Variables

http://medcraveonline.com/JOENTR/volume_issues?issueId=1343&volumeId=415

Repercussões minerais ósseas no alcoolismo crônico associado à deficiência hormonal em ratos

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