Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum

Baureithel, Karl H.; Büter, Karin Berger; Engesser, Anja; Burkard, W. P.; Schaffner, W.

doi:10.1016/s0031-6865(97)00002-2

Cited by 94 publications

(43 citation statements)

References 9 publications

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“…The EtOAc fraction (3.0 g) was placed on a silica gel (300 g, 4.8ϫ45 cm) column and eluted using a C-NMR data, for amentoflavone, were identical to those reported in literature. 17,23,24) The Effects of Sodium Azide (NaN 3 ) on Antifungal Activity To investigate the effects of NaN 3 on the antifungal activity of amentoflavone in C. albicans, its activity was determined either in the absence or presence of 0.002% NaN 3 . The subcultured C. albicans cells were cultured at a half of MIC in the absence or presence of 0.002% NaN 3 .…”

Section: Plant Material Fungal Strains and Growth Conditionmentioning

confidence: 99%

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S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

Jung

Park

Lee

et al. 2007

Biological & Pharmaceutical Bulletin

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Section: Plant Material Fungal Strains and Growth Conditionmentioning

confidence: 99%

“…2). These percentages represent average of measurements conducted in triplicate, and each independent assay did not display any significant differences according to NaN 3 .…”

Section: Isolation and Purification Of Amentoflavonementioning

confidence: 99%

S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

Jung

Park

Lee

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The pharmacological activity of SJW extracts has recently been reviewed (Butterweck, 2003;Greeson et al, 2001;Nathan, 1999). Reports about the antidepressant activity of SJW extracts and their constituents both in vivo and in vitro have been published (Baureithel et al, 1997;Butterweck et al, 1997Butterweck et al, , 1998Butterweck et al, , 2000Butterweck et al, , 2001aButterweck et al, , b, 2002Calapai et al, 1999;Chatterjee et al, 1996Chatterjee et al, , 1998aDi Matteo et al, 2000;Franklin and Cowen, 2001;Gobbi et al, 1999Gobbi et al, , 2001Müller et al, 1997Müller et al, , 1998Müller et al, , 2001Simmen et al, 1999Simmen et al, , 2001Singer et al, 1999;Wonnemann et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Hyperforin-Containing Extracts of St John's Wort Fail to Alter Gene Transcription in Brain Areas Involved in HPA Axis Control in a Long-Term Treatment Regimen in Rats

Butterweck

Winterhoff²,

Herkenham

2003

Neuropsychopharmacol

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We previously showed that a methanolic extract of St John's wort (SJW) (Hypericum) and hypericin, one of its active constituents, both have delayed regulation of genes that are involved in the control of the hypothalamic-pituitary-adrenal (HPA) axis. Hyperforin, another constituent of SJW, is active in vitro and has been proposed to be the active constituent for therapeutic efficacy in depression. We therefore examined if hyperforin has delayed effects on HPA axis control centers similar to those of Hypericum and hypericin. We used in situ hybridization histochemistry to examine in rats the effects of short-term (2 weeks) and long-term (8 weeks) oral administration of two hyperforin preparations, fluoxetine (positive control), and haloperidol (negative control) on the expression of genes involved in the regulation of the HPA axis. Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropinreleasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus. Fluoxetine increased levels of mineralocorticoid (MR) (17%), glucocorticoid (GR) (18%), and 5-HT 1A receptor (21%) mRNAs in the hippocampus at 8, but not 2, weeks. Comparable to haloperidol (1 mg/kg), neither the hyperforinrich CO 2 extract (27 mg/kg) nor hyperforin-trimethoxybenzoate (8 mg/kg) altered mRNA levels in brain structures relevant for HPA axis control at either time point. These data suggest that hyperforin and hyperforin derivatives are not involved in the regulation of genes that control HPA axis function.

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“…GABA'nın GABA A ve GABA B reseptörlerine bağlanması önemli bir sinir inhibisyonu sağlar. GABA bağlanmasındaki bu azalma merkezi sinir sisteminde depresyonu azaltmayla sonuçlanır 21,22 . Üçüncü mekanizma beynin frontal korteksinde serotonin (5-HT 2 ) reseptörlerinin yoğunluğunun ve sayısının artmasıdır ki; bu depresyonun iyileşmesinde potansiyel olarak yararlıdır.…”

Section: Kantaron Bitkisinin Depresyona Etki Mekanizmasıunclassified

Sarı Kantaron (Hypericum Perforatum) ile Orfanin Etkileşiminin Depresyon Tedavisindeki Rolü

Yalçın¹,

Boğa²,

Pekmezekmek³

2015

Arşiv Kaynak Tarama Dergisi

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St. John's Wort (Hypericum perforatum/ Cantarion) has been well-studied which has been showed to have antidepressant, antiviral, and antibacterial effects. St John's Wort gained popularity as an alternative treatment for mild to moderate depression. On the other hand, the neuropeptide, orphanin FQ/nociceptin (OFQ/N), is expressed in both neuronal and non-neuronal tissue. In the brain, OFQ/N has been investigated in relation to stress, anxiety, learning and memory, and addiction. The purpose opf this article is to review the current pharmacological, and clinical papers on St. John's wort, to provide information on orphanin FQ/nociceptin and finally to evaluate probable interaction between two.

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Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum

Cited by 94 publications

References 9 publications

S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

Hyperforin-Containing Extracts of St John's Wort Fail to Alter Gene Transcription in Brain Areas Involved in HPA Axis Control in a Long-Term Treatment Regimen in Rats

Sarı Kantaron (Hypericum Perforatum) ile Orfanin Etkileşiminin Depresyon Tedavisindeki Rolü

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