Inhibition of B16 murine melanoma metastasis and enhancement of immunity by fever-range whole body hyperthermia

Jia, Dawei; Rao, Wei; Wang, Chao; Jin, Chao; Wang, Suqiong; Chen, Dongwei; Zhang, Minghui; Guo, Jia; Chen, Zhijie; Liu, Jing

doi:10.3109/02656736.2011.559613

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…1 Failure to treat these types of cancers by conventional therapy has enthused interest in the development of newer strategies. 2 Hyperthermia or heat therapy (typically to the tune of 41°C-47°C) is a promising strategy to combat cancers. 3 Tumor tissues are reported to be more susceptible to high temperatures as compared to normal tissues due to impaired heat dissipation.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Haghniaz

Umrani

Paknikar

2016

IJN

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Purpose The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice. Materials and methods Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment. Results Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”. Conclusion The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer.

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Section: Introductionmentioning

confidence: 99%

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Haghniaz

Umrani

Paknikar

2016

IJN

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“…[4][5][6][7][8] Fever-level whole body hyperthermia (∼39°C-41°C) can mitigate many of these side effects and has potential to be an effective cancer treatment, but this lower heat level is thought, primarily, to stimulate the immune system and the benefits of direct thermal toxicity are reduced. 9,10 Generating localized hyperthermia at the cancer site could alleviate many of the side effects associated with whole body hyperthermia while still taking advantage of the thermal susceptibility of tumors.…”

Section: Introductionmentioning

confidence: 99%

Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Basel¹,

Balivada²,

Wang³

et al. 2012

IJN

114

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Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/ iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/ macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/ iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.

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“…As mentioned previously, the high expression of cytokines in the spleen activates CTLs, NK cells, macrophages and monocytes, and results in increased death of tumor cells in situ. However, the expression of TNF-α mRNA in the spleen decreased slightly in the 46˚C group compared with those in the control group, while TNF-α protein was found to be either increased or unchanged in serum following early ablation (10) or mild hyperthermia (26). Further investigation is needed to explain these divergent results.…”

Section: Discussionmentioning

confidence: 54%

“…Previously, it has been reported that hyperthermia induces a Th1-dominant immune response. The protein concentration of cytokines IL-2, IFN-γ and TNF-α was shown to increase in the peripheral blood following whole body or local hyperthermia (10,(24)(25)(26). The spleen is the largest immune organ in the body, and contains a large number of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effect and immune response induced by local hyperthermia in B16 murine melanoma: Effect of thermal dose

Tang

Zhao

et al. 2012

Oncology Letters

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Abstract. This study aimed at investigating the antitumor effect and immune response induced by local high-temperature hyperthermia at different thermal doses in B16 murine melanoma. The screened optimal thermal dose (50˚C, 15 min) which was demonstrated to be the most effective in immune response activation was applied to the treatment of lung metastasis. The optimal thermal dose was determined by evaluating the tumor volume change, survival period of tumorbearing mice, and immune indices including interleukin (IL)-2, interferon (IFN)-γ and TNF-α mRNA expression in the spleen of mice subjected to local hyperthermia at various thermal doses. The activation of the immune response was further investigated by rechallenging the cured mice 60 days after hyperthermia treatment. The screened optimal thermal dose combined with immunoadjuvant compound 48/80 was applied for melanoma lung metastasis. While local hyperthermia effectively inhibited B16 melanoma tumor growth and prolonged the survival period of tumor-bearing mice, the antitumor immunity was significantly enhanced and the effect was thermal dose-dependent. Higher temperatures (≥50˚C) induced a significant effect even with a short treatment time (≤15 min). No tumor regrowth was observed for rechallenged B16 melanoma in mice following treatment with local hyperthermia at a higher temperature. Local hyperthermia by optimal thermal dose in combination with immunoadjuvant compound 48/80 is an effective approach for the treatment of B16 melanoma lung metastasis. This study indicated that the use of a local high-temperature hyperthermia protocol inhibits tumor growth and stimulates a favorable antitumor immune response against malignant melanoma. The results of these experiments may have clinical significance for the treatment of melanoma.

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Inhibition of B16 murine melanoma metastasis and enhancement of immunity by fever-range whole body hyperthermia

Abstract: The whole body hyperthermia protocol described in this work inhibits B16 tumour metastasis by inhibiting cell proliferation, neovascularisation and stimulating favourable immune responses. It demonstrated that WBH treatment benefits therapy of metastasis cancers.

Cited by 15 publications

References 40 publications

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Antitumor effect and immune response induced by local hyperthermia in B16 murine melanoma: Effect of thermal dose

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