Inhibition of avian myeloblastosis virus reverse transcriptase and virus inactivation by metal complexes of isonicotinic acid hydrazide

Vasudevachari, M. B.; Antony, A.

doi:10.1016/0166-3542(82)90052-3

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…The result is inactivation of the pathogen. Also copper complexes can form radicals that inactivate viruses (Vasudevachari and Antony, 1982). Copper may also disrupt enzyme structures and functions by binding to sulfur or carboxylate containing groups and amino groups holes in the cell membranes, thereby compromising the integrity of cells of proteins and can interact with lipids, causing their peroxidation and opening holes in the cell membranes, thereby compromising the integrity of cells.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

Hasabi

Askari

Alavi

et al. 2014

Turkish JAF Sci.Tech.

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Asiatic citrus canker caused by Xanthomonas citri subsp. citri is becoming a disease of high economic impact, affecting all types of important citrus crops. In this study, the potential antibacterial activity of ten organic and inorganic salts on X. citri subsp. citri and on citrus canker disease development was evaluated. Among the salt compounds, copper, iron and zinc inorganic salts particularly zinc (with the highest diameter of inhibition, the lowest MIC and MBC values and the highest bacterial growth inhibitory effect) had direct antibacterial activity and strongly reduced the development of canker disease and bacterial population of lime plants.

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Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

Hasabi

Askari

Alavi

et al. 2014

Turkish JAF Sci.Tech.

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“…Despite its long history of use, the antimicrobial capabilities of chitosan against a spectrum of Gram-positive and Gram-negative bacteria were formally recognised in 1979 [1] and a whole range of studies began [2][3][4][5][6][7][8][9][10]. The antimicrobial ability of this natural animal-based polysaccharide relies on a number of factors including pH, microorganism species, metal ion content, molecular weight, degree of deacetylation and so forth [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the antibacterial properties of chitosan fibres embedded with copper ions for wound dressing applications

Barnabas

Miraftab

Qinand

et al. 2013

Journal of Industrial Textiles

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Chitosan is a natural polymer that is well known for its inherent antimicrobial ability and natural healing properties and hence it has been developed into fibres that are used for wound dressing applications. To increase its antimicrobial potency, these fibres are treated with copper sulphate. In a wound environment, copper ions have potent antimicrobial abilities due to their propensity to bind with proteins and ability to produce hydrogen peroxides. In this article, copper-treated chitosan fibres of different concentrations have been tested and analysed to determine the most effective antimicrobial dose for potential wound care dressings. Selected common skin microflora, i.e. Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus, have been used to test the chitosan-copper combinations. The analysis, based on the test methods of zone of inhibition, spectrophotometry and plating technique, has shown that copper concentration of 0.3 gm/ml was highly effective against the three bacteria and could potentially be most suitable formulation for wound dressing applications.

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“…It has been reported that CunINH inhibits the multiplication of avian myeloblastosis virus by blocking the process of reverse transcription (Vasudevachari & Antony, 1985a). This inhibition was shown to be due to preferential binding of CuHINH to the enzyme reverse transcriptase (Vasudevachari & Antony, 1982). Recently, it has been shown that Cu'^NH cleaves pBR322 form I DNA into smaller fragments (Vasudevachari & Antony, 1985b).…”

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confidence: 99%

Studies on the interaction of cupric isonicotinohydrazide with DNA

Divakar¹,

Vasudevachari²,

Antony³

et al. 1987

Biochemistry

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The interaction of cupric isonicotinohydrazide (CuIIINH), an antiviral compound, with calf thymus DNA was investigated by circular dichroism (CD) and nuclear magnetic resonance (NMR). Gel electrophoresis of DNA incubated with CuIIINH showed cleavage of DNA to various extents. This cleavage was found to be time and concentration dependent. In the presence of CuIIINH the positive CD band at 274 nm disappeared and the negative band at 246 nm showed a decrease in the mean residual ellipticity value, indicating binding of CuIIINH to DNA. 31P NMR studies indicated that the binding of copper in CuIIINH is to the phosphate oxygen of the DNA backbone. The binding of CuIIINH was also found to be reversible. Addition of ethylenediaminetetraacetic acid to the CuIIINH-DNA complex resulted in breaking of the complex and restoring the original structural features of the B family of DNA in the resulting fragments. At the concentration level of CuIIINH employed, both CuSO4 and INH independently did not show any interaction with DNA.

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Inhibition of avian myeloblastosis virus reverse transcriptase and virus inactivation by metal complexes of isonicotinic acid hydrazide

Cited by 10 publications

References 19 publications

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

Evaluating the antibacterial properties of chitosan fibres embedded with copper ions for wound dressing applications

Studies on the interaction of cupric isonicotinohydrazide with DNA

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