Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005

Gardiner, P.J.; Cuthbert, Nigel J.; Francis, Hilary P.; Fitzgerald, Mary; Thompson, Angela; Carpenter, Tracey G.; Patel, Umesh; Newton, Benjamin B.; Mohrs, K. H.; Müller‐Peddinghaus, R.; Taylor, William A.

doi:10.1016/0014-2999(94)90061-2

Cited by 19 publications

(5 citation statements)

References 6 publications

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“…The effects of inhibition of cysLTs in experimental models of acute pulmonary responses to antigen have been previously studied in GP. Gardiner et al [25] observed that the inhibition of leukotriene synthesis resulted in an attenuation of OVA‐induced airway contraction sensitized GP. Liu et al [26] demonstrated that the CysLT 1 receptor antagonists pranlukast and zafirlukast inhibited OVA‐induced mucus secretion in the trachea of sensitized GP.…”

Section: Discussionmentioning

confidence: 99%

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea‐pigs

Leick-Maldonado

Kay

Leonhardt

et al. 2004

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea‐pigs

Leick-Maldonado

Kay

Leonhardt

et al. 2004

Clin Experimental Allergy

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“…Considering studies in animal models, Gardiner et al (74) observed that the inhibition of leukotriene synthesis resulted in an attenuation of OVA-induced airway contraction in sensitized animals. Liu et al (75) demonstrated that the CysLT1 receptor antagonists pranlukast and zafirlukast inhibited OVA-induced mucus secretion in the trachea of a sensitized guinea pig.…”

Section: Cysteinyl Leukotrienesmentioning

confidence: 99%

Different Modulators of Airways and Distal Lung Parenchyma Contractile Responses in the Physiopathology of Asthma

Prado¹,

Tibério²

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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In addition, ASM can contribute to lung inflammation. Many studies showed that there was an increased number of mast cells in the asthmatic ASM layer (33-38). Brightling et al. (32) evaluated patients with asthma and eosinophilic bronchitis and observed that both groups showed an increase in eosinophils but that the patients with eosinophilic bronchitis were not hyperresponsive to bronchoconstrictor stimuli. The analysis of the ASM layers in these patients showed that only the asthmatics showed a higher number of mast cells and a worsening of respiratory function, suggesting that the mast cells present in the ASM of asthmatics are responsible for the enhancement of airway narrowing. The ASM cells release chemotactic agents for mast cells, such as CCL11 (25), CXCL10 (34) and CX3CL1 (35). Because the mast cells are in the airways, they adhere to the ASM cells and produce, together with the eosinophils, contractile mediators, such as prostaglandins (PGF2, PGD2, and thromboxane TXA2) (39). Clinically, the AHR symptoms are described as cough, tightness of the chest and wheezing after exercise or exposure to cold air or other environmental irritants (40). Some studies suggest that monitoring of the AHR in asthmatic patients can serve as a guide to asthma therapy (24). Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues-From Molecules to Humans 318 Considering that many patients with AHR respond fairly well to conventional therapies, such as anti-inflammatory and bronchodilator drugs, and that ASM remodeling is insensitive to these treatments, further studies are necessary to evaluate ways to prevent or reverse ASM remodeling.

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“…Part of the difficulty in interpreting and comparing these compounds is the variation among test methods and activity criteria 18 . A commonly used model is antigen‐induced bronchoconstriction test in sensitized guinea pigs, because it can be easily manipulated to evaluate LT synthesis inhibition 98,99 . Many of the older compounds had poor systemic activity due to the poor absorption and instability and, thus, had limited clinical application 18 .…”

Section: Asthma Allergic Rhinitis and Ltmentioning

confidence: 99%

“…18 A commonly used model is antigen-induced bronchoconstriction test in sensitized guinea pigs, because it can be easily manipulated to evaluate LT synthesis inhibition. 98,99 Many of the older compounds had poor systemic activity due to the poor absorption and instability and, thus, had limited clinical application. 18 Most recently, however, LT receptor antagonists and inhibitors that have good oral absorption have been developed and used successfully in the management of asthma and allergic rhinitis in humans.…”

Section: Leukotriene Inhibitorsmentioning

confidence: 99%

Update on the role of leukotrienes in the pathogenesis of atopy: a comparative review

Marsella

2001

Veterinary Dermatology

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The pathogenesis of atopic disease (AD) is controversial in humans and dogs. In humans, leukotrienes (LT) are thought to play an important role in this disease and LT inhibitors are commonly used as treatment for AD. Leukotrienes are a heterogeneous group of biologically active compounds that mediate many aspects of inflammatory and allergic reactions. This paper will review the role of LT in atopic disease in a comparative manner. Leukotriene inhibitors and their therapeutic use in the management of atopic disease in humans and dogs are discussed.

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Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005

Cited by 19 publications

References 6 publications

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea‐pigs

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea‐pigs

Different Modulators of Airways and Distal Lung Parenchyma Contractile Responses in the Physiopathology of Asthma

Update on the role of leukotrienes in the pathogenesis of atopy: a comparative review

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