Inhibition of Antidiuretic Hormone Secretion by Diphenylhydantoin

Fichman, Marshal P.; Kleeman, Charles R.; Bethune, John E.

doi:10.1001/archneur.1970.00480190049008

Cited by 71 publications

(25 citation statements)

References 5 publications

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“…Few medications have been reported to cause central diabetes insipidus. Phenytoin is one example, inhibiting antidiuretic hormone secretion and increasing urine volume, putting patients at risk for hypernatremia (39).…”

Section: Euvolemicmentioning

confidence: 99%

Electrolyte disturbances associated with commonly prescribed medications in the intensive care unit

Buckley

LeBlanc²,

Cawley³

2010

Critical Care Medicine

110

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Electrolyte imbalances are common in critically ill patients. Although multiple disease states typically encountered in the intensive care unit may be responsible for the development of electrolyte disorders, medications may contribute to these disturbances as well. Medications can interfere with the absorption of electrolytes, alter hormonal responses affecting homeostasis, as well as directly impact organ function responsible for maintaining electrolyte balance. The focus on this review is to identify commonly prescribed medications in the intensive care unit and potential electrolyte disturbances that may occur as a result of their use. This review will also discuss the postulated mechanisms associated with these drug-induced disorders. The specific drug-induced electrolyte disorders discussed in this review involve abnormalities in sodium, potassium, calcium, phosphate, and magnesium. Clinicians encountering electrolyte disturbances should be vigilant in monitoring the patient's medications as a potential etiology. Insight into these drug-induced disorders should allow the clinician to provide optimal medical management for the critically ill patient, thus improving overall healthcare outcomes.

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Section: Euvolemicmentioning

confidence: 99%

Electrolyte disturbances associated with commonly prescribed medications in the intensive care unit

Buckley

LeBlanc²,

Cawley³

2010

Critical Care Medicine

110

View full text Add to dashboard Cite

show abstract

“…The excretion of a large volume of hypotonic urine in this hypematremic patient suggested the diagnosis of central diabetes insipidus. The clinical diagnosis was central diabetes insipidus caused by the acute pneumococcal meningitis and possibly inhibition of ADH release by Dilantin [17,18], Up to this point, the case is rather straightforward.…”

Section: Hypernatremia Due To Excretion Of a Large Volume Of Hypotonimentioning

confidence: 99%

Pathophysiological Approach to Patients Presenting with Hypernatremia

Marsden¹,

Halperin²

1985

Am J Nephrol

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“…Although the practice of drug monitoring has probably reduced the incidence of hypona tremia in CBZ-trcatcd epileptic patients, many subjects may still be susceptible to electrolyte disturbances. In fact, even if CBZtreated subjects have normal plasma sodium concentrations and osmolality, their capacity to excrete a water load may be grossly altered [Perruca et al, 1978], Also, since PHT, which inhibits antidiuretic hormone release [Fichman et al" 1970], determines a neuropathy accompanying long-term medication, it is tempting to speculate that because of the sim ilarities of the two drugs, other mechanisms may cause the affection.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Therapy with Carbamazepine: Effects on Nerve Conduction Velocity

et al. 1983

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Peripheral nerve function was evaluated in 30 epileptic patients on chronic therapy with carbamazepine (CBZ) and 20 healthy controls. The electrophysiological data indicated a mild progressive reduction of both motor and sensory conduction velocity in the patients on long-term treatment with the drug. The impairment of nerve function paralleled the duration of therapy (i.e. 1 through 3 years). CBZ plasma levels were constantly within the therapeutic range. Folic acid levels were below normal in about 50% of the subjects. In the absence of other evidence, the hypothesis cannot be excluded that folate deficiency may have played some role in the development of the peripheral nerve dysfunction.

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Inhibition of Antidiuretic Hormone Secretion by Diphenylhydantoin

Cited by 71 publications

References 5 publications

Electrolyte disturbances associated with commonly prescribed medications in the intensive care unit

Electrolyte disturbances associated with commonly prescribed medications in the intensive care unit

Pathophysiological Approach to Patients Presenting with Hypernatremia

Long-Term Therapy with Carbamazepine: Effects on Nerve Conduction Velocity

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