Inhibition of Antibody Formation to Sheep Erythrocytes by Various Tumour-Inhibiting Chemicals

Fm, Dietrich

doi:10.1159/000229713

Cited by 23 publications

(8 citation statements)

References 4 publications

(5 reference statements)

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“…The results of varying the substance regimens are summarized in table I. Animals treated with the highest dose of 1.3-BPP [Dietrich, 1966]. Table II (approximately 50%> DL50) [Urban, unpubl.…”

Section: Resultsmentioning

confidence: 99%

Immunosuppressive Effects of Barbituric Acid Derivatives

Güttner¹,

Heinecke²,

Küchler³

et al. 1973

Chemotherapy

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The effect of intraperitoneally applied 1.3-bis(piperidinomethyl)-5-ethyl-5-phenyl-barbituric acid on immune response in mice has been investigated. A marked depression of antihuman erythrocyte agglutinin titers was found following primary and secondary immunization; in the latter it mainly concerned 2-mercaptoethanol resistant antibodies. The immunological memory was influenced, too. The effects on humoral antibody reaction were dependent on dosage and timing. Chronic substance administration produced a lower progression of autoimmune nephropathy in (NMRI×NZB)F₁ hybrid mice as evaluated by immunofluorescence photometry. However, the depression of circulating hemagglutinins did not coincide with a concomitant inhibition of cell-mediated immunity as examined by means of contact sensitivity and skin allografting in mice and phytohemagglutinin-stimulated human lymphocytes in vitro.

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Section: Resultsmentioning

confidence: 99%

Immunosuppressive Effects of Barbituric Acid Derivatives

Güttner¹,

Heinecke²,

Küchler³

et al. 1973

Chemotherapy

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“…Thus, cyclophospha mide and 6-mercaptopurinc were found to have an effect quite com parable to that seen in experiments where inhibition of circulating antibodies was examined [8]. Fluorinated steroid compounds ex hibiting a smaller activity than cyclophosphamide and 6-mercaptopurine as regards suppression of circulating antibodies to sheep eryth rocytes [9,11] were shown in this study to produce a considerably greater effect than the alkylating agent and the antimetabolite tested.…”

Section: Discussionmentioning

confidence: 64%

Hypersensitivity in Mice

Dietrich¹,

Hess²

1970

Int Arch Allergy Immunol

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“…IgM and IgG were differentiated by means of 2-mercaptoethanol (2-ME). The immunosuppressive effect was expressed as suppressive index (SI), i.e., the ratio of the mean log2-titres of treated to that of control animals [3]. Values of SI < 0.87 represent statistically significant differences between the titres of treated animals and controls (Student's t-test P = 0.05).…”

Section: (E) Humoral Antibody Assaysmentioning

confidence: 99%

β-[1-phenyl-5-bis(β-chloroethyl)-amino-benzimidazolyl-(2)]-Dl-alamine (ZIMET 3164): An immunosuppressant without marked anti-cancer effect

et al. 1979

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ZIMET 3164 inhibited the growth of sarcoma 180 P, sarcoma 180 G, and Walker 256 carcinosarcoma, but was unable to prolong the survival time of mice bearing Ehrlich ascites carcinoma or the leukaemias L 1210 and LAJ I to a worthwhile extent. The primary and secondarantly suppressed in mice. The drug exerted maximum effect when given on days--2 to +2 relative to antigenic stimulus. Administration exclusively prior to immunization induced only moderate immunosuppression while injection afterwards failed to affect the primary response at all, suggesting that the drug interfers with the afferent limb of immune response. In general, ZIMET 3164 proved to be half as effective as cyclophosphamide, but more effective than chlorambucil.

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Inhibition of Antibody Formation to Sheep Erythrocytes by Various Tumour-Inhibiting Chemicals

Cited by 23 publications

References 4 publications

Immunosuppressive Effects of Barbituric Acid Derivatives

Immunosuppressive Effects of Barbituric Acid Derivatives

Hypersensitivity in Mice

β-[1-phenyl-5-bis(β-chloroethyl)-amino-benzimidazolyl-(2)]-Dl-alamine (ZIMET 3164): An immunosuppressant without marked anti-cancer effect

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