Inhibition of androgen‐sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of antiproliferative action of the pineal hormone with mt1 receptor protein expression

Xi, Si C.; Siu, Stephanie; Fong, Sze Wan; Shiu, Stephen Y. W.

doi:10.1002/1097-0045(200101)46:1<52::aid-pros1008>3.3.co;2-q

Cited by 31 publications

(51 citation statements)

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“…Therefore, potential anti-prostate cancer strategies may include effective apoptosis induction or enhancement via novel apoptosis inducers [123]. Xi et al [134] demonstrated the antiproliferative effects of melatonin on prostate cancer cell proliferation and apoptosis in athymic nude mice xenograft models of LNCaP and PC-3 cells. Melatonin inhibited the growth of LNCaP tumors, without affecting the growth of PC-3 xenografts, in nude mice; the indoleamine also induced significant decreases in the expression of PCNA, cyclin A, and PSA in LNCaP tumors.…”

Section: Prostate Cancermentioning

confidence: 99%

Melatonin, A Natural Programmed Cell Death Inducer in Cancer

Sánchéz-Hidalgo

Guerrero²,

Villegas

et al. 2012

CMC

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Melatonin, an indolamine derived from the amino-acid tryptophan, participates in diverse physiological functions and has great functional versatility related to the regulation of circadian rhythms and seasonal behaviour, sexual development, retinal physiology, tumour inhibition, as an antioxidant, immunomodulatory and anti-aging properties. In relation to its oncostatic properties, there is evidence that tumor initiation, promotion or progression may be restrained by the night-time physiological surge of melatonin in the blood or extracellular fluid. In addition, depressed nocturnal melatonin concentrations or nocturnal excretion of the main melatonin metabolite, 6-sulfatoxymelatonin, were found in individuals with various tumor types. In the majority of studies, melatonin was shown to inhibit development and/or growth of various experimental animal tumors and some human cell lines in vitro. Many tumors do not respond to drug treatment due to their resistance to undergo apoptosis thereby contributing to the development of cancer. Thus, given the importance of the apoptotic program in cancer treatment, the role of melatonin in influencing apoptosis in tumor cells attracted attention because it seems that it actually promotes apoptosis in most tumor cells, in contrast to the obvious inhibition of apoptotic processes in normal cells. Thus, this paper is also intended to provide to the reader an up-date of all the researches that have been carried out to date, which investigate the proapoptotic effects of melatonin in experimental preclinical models of cancer (in vitro and in vivo) and the underlying proposed action mechanism of this effects. If melatonin uniformly induces apoptosis in cancer cells, the findings could have important clinical implications to improve the quality of live while preventing the appearance of cancer.

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Section: Prostate Cancermentioning

confidence: 99%

Melatonin, A Natural Programmed Cell Death Inducer in Cancer

Sánchéz-Hidalgo

Guerrero²,

Villegas

et al. 2012

CMC

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“…In fact, a few authors (14) showed that melatonin was an antiproliferative agent, reducing PCNA expression in hormone-dependent tumors in mouse prostate glands, both in cell culture and in vivo. Those authors suggested that the effect of melatonin might be due to the link between melatonin MT1 receptor and neoplastic cells.…”

Section: Figurementioning

confidence: 99%

“…This fact suggests that melatonin regulates tumor growth (13). Studies also show that melatonin is an antiproliferative agent that decreases proliferating cell nuclear antigen (PCNA) expression in hormone-dependent tumors in mice (14). Therefore, the present study aims to investigate the effects of melatonin on ovarian histology and on VEGF and PCNA expression as well as its action on sex steroids and their receptors in pinealectomized adult female rat ovaries.…”

mentioning

confidence: 98%

Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats

Romeu

Motta

Maganhin

et al. 2011

Fertility and Sterility

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“…Recently, both in vitro and in vivo investigations have demonstrated that melatonin also has important oncostatic properties [1,2]. Studies have veriWed that melatonin is involved in the prevention of tumor initiation, promotion, and progression.…”

Section: Introductionmentioning

confidence: 99%