Inhibition of an Ehrlich Ascites Tumor In Vivo by Partially Neutralized Solutions of Sodium Lactate

Stevens, CA; Atchley, R; Herzog, Wilhelm; Feldhake, Charles J.; Turner, Malcolm E.

doi:10.1038/bjc.1963.45

Cited by 1 publication

(2 citation statements)

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“…Mice were handled and treated as previously described [53]. About 850 albino mice were inoculated with Ehrlich ascites tumor cells using two or more donors for each experi ment.…”

Section: Methodsmentioning

confidence: 99%

“…Because a pH as low as 5 would presumably not be realizable in solid tu mors, further experimentation was at pHs of 6 and above. At these pHs there is little effect of hydrogen ions on survival (last experiment in table II) [53,62]. At the same time, sodium phosphate buffers were substituted for the sul fonamide partly with the idea of increasing the rate of glycolysis by tumor cells [31,68], sodium being preferred to potassium as less toxic i.v.…”

Section: In Vivo Experimentsmentioning

confidence: 99%

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Influence of pH on the Effect of Hexamethylenetetramine on the Growth of Ehrlich Ascites Tumors

Stevens¹,

Lehman²

1973

Oncology

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Inhibition of the growth of Ehrlich tumors by i. p. injection of hexamine increased as the pH of the solution was decreased from 7.4 to 6. Survival of the mice was correspondingly prolonged. Median survivals were 16.5, 23, and 25 days for mice given 5 daily injections of 50 ml/kg body weight of 0.8 m hexamine in 0.3 m glucose at pHs of 7.4, 6.4, and 6.0, respectively, beginning the day after tumor inoculation. Median survivals were 16.5 and 28.5 days after a single injection of 400 ml/kg of 0.06 _M hexamine at pHs of 7 and 5, respectively, while similar solutions at pHs 7 and 5 without hexamine gave medians of 15.5 and 21.5 days, respectively. In vitro at pH 6.4 and 37°C some ascites cells survived in 0.8 m hexamine for 40 min, but none for 65 min; survival was measured by ability to produce tumors. Glucose had an additional small deleterious effect.

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“…Mice were handled and treated as previously described [53]. About 850 albino mice were inoculated with Ehrlich ascites tumor cells using two or more donors for each experi ment.…”

Section: Methodsmentioning

confidence: 99%

Section: In Vivo Experimentsmentioning

confidence: 99%