Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract

Abstract

Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer’s disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. However, recent studies considered that the phenylethanoid glycosides may be metabolized by intestinal bacteria, because all analysis results showed that the bioavailability of phenylethanoid glycosides is extremely low. In this study we demonstrate how iron chelation plays a crucial role in the Aβ aggregation and deposition inhibition mechanism of phenylethanoid glycosides of CTE. In addition, we further proved phenylethanoid glycosides (1–3) could reach brain. Active CTE component and action mechanism confirmation will be a great help for product quality control and bioavailability studies in the future. At the same time, we provide a new analysis method useful in determining phenylethanoid glycosides (1–3) in plants, foods, blood, and tissues for chemical fingerprint and pharmacokinetic research.

Protective effect of Cistanche deserticola on gentamicin-induced nephrotoxicity in rats

“…Red ginseng extract treatment significantly attenuated tubular damage, renal dysfunction and cell apoptosis and decreased ROS production in GM-induced rats ( Ansari et al, 2016 ). C. deserticola is an important traditional Chinese herbal for renal dysfunction treatment ( Chao et al, 2019 ). Decoction or medicinal liquor of this plant have been widely used.…”

Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease Complicated With Osteoporosis

“… Zhou et al (2019 ) found that the CH extract had antiapoptotic and antioxidant stress effects via inhibiting Aβ deposition and tau protein hyperphosphorylation and promoting synapse protection. Chao et al (2019 ) also discovered that the CH extract protected against AD by inhibiting Aβ peptide aggregation and deposition. In a clinical trial, AD patients were treated with CH capsules for 48 weeks.…”

A Sample Preparation Technique Using Biocompatible Composites for Biomedical Applications

“…Here, an efficient method for fabricating a cucurbituril-decorated, amine-modified diatom composite (CB–DA) is proposed, and the usefulness of this CB–DA composite for efficient sample enrichment and in situ nucleic acid preparation from pathogens and cells is demonstrated. The well-characterized process of amino functionalization of the surface of DE renders it a universal tool for targeting molecules, and cucurbit[6]uril (CB) has been introduced to enhance the ability of CB–DA composites to rapidly and efficiently adsorb molecules [3,16,17]. We have also verified that modification with 3-aminopropyl-methyl-diethoxysilane (APDMS) is more effective than traditional modification with 3-aminopropyl-triethoxysilane (APTES).…”