Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration
Basma Sukkar,
Lalehan Oktay,
Ayse Sahaboglu
et al.
Abstract:The expressions of ion channels by Müller glial cells (MGCs) may change in response to various retinal pathophysiological conditions. There remains a gap in our understanding of MGCs' responses to photoreceptor degeneration towards finding therapies. The study explores how an inhibition of store‐operated Ca2+ entry (SOCE) and its major component, Orai1 channel, in MGCs protects photoreceptors from degeneration. The study revealed increased Orai1 expression in the MGCs of retinal degeneration 10 (rd10) mice. En… Show more
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