Inhibition of Allergic Bronchoconstriction in Guinea Pigs and in Asthmatics by the Leukotriene Antagonist ONO-1078

Nakagawa, Takemasa; Yamashita, Naomi; Mizushima, Yutaka; Ishii, Akira; Itō, Kōji; Nambu, Fumio; Motoishi, Mariko; Yui, Yasuo; Shida, Takao; Miyamoto, Terumasa

doi:10.1159/000236321

Cited by 3 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…Currently, glucocorticoids, β2 agonists and leukotriene modulators are mostly used in the treatment of AA to provide rapid relief of asthma exacerbations, reduce bronchoconstriction, and decrease airway inflammation. 2,3 However, there are still some patients with unsatisfactory treatment results and long-term use of such drugs can produce significant toxic side effects. Traditional Chinese medicine has been studied extensively in the treatment of allergic diseases such as asthma, and has definite clinical efficacy, especially in reducing the side effects of western drugs, and long-term use does not reduce immunity.…”

Section: Introductionmentioning

confidence: 99%

Modified Haoqin Qingdan Decoction Exerts Antioxidant Effect via Activating PI3K/Akt/Nrf2 Pathway on Allergic Asthma Mice

Dong,

Zhang,

et al. 2024

Natural Product Communications

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Objective The aim of this study was to investigate the antioxidant effect and potential mechanism of Modified Haoqin Qingdan Decoction on ovalbumin (OVA)-induced allergic asthma (AA) mice. Methods The AA model of mice was induced by OVA combined with aluminum hydroxide. Resistance Index (RI) in airway was analyzed by AniRes2005 animal pulmonary function analyzer. H&E staining was used to evaluate the pathological changes of lung tissue. The apoptosis in lung tissue was detected by TUNEL staining. The percentage of EOS cells in bronchoalveolar lavage fluid was determined by flow cytometry. The levels of IL-1β, IL-6, IL-4, GM-CSF, TNF-α, and IFN-γ in serum were determined by ELISA. Biochemical kits were used to detect levels of SOD, MDA, and GSH-Px in lung tissue. The protein expression of PI3K, p-PI3K, Akt, p-Akt, and nucleoprotein Nrf-2 in lung tissue was detected by western blotting. Result Modified Haoqin Qingdan Decoction reduced RI, alleviated the degree of histopathological damage, inhibited apoptosis rate, reduced the proportion of EOS cells, downregulated IL-1β, IL-6, IL-4, GM-CSF, TNF-α, IFN-γ, and MDA, upregulated SOD, GSH-Px, p-PI3K, p-Akt, and nucleoprotein Nrf-2. Conclusion Modified Haoqin Qingdan Decoction activated nucleoprotein Nrf2 by regulating the PI3K/Akt signaling pathway to exert its protective effect against inflammatory and oxidative stress in AA mice.

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Section: Introductionmentioning

confidence: 99%

Modified Haoqin Qingdan Decoction Exerts Antioxidant Effect via Activating PI3K/Akt/Nrf2 Pathway on Allergic Asthma Mice

Dong,

Zhang,

et al. 2024

Natural Product Communications

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“…Elevated levels of these mediators have been associated with the key features of the disease including, increased vascular permeability, airway obstruction, mucus hypersecretion, and leukocytic infiltration of pulmonary tissue . The improvement of acute airway function in asthmatic patients upon administration of either a peptidoleukotriene antagonist or a 5-LO inhibitor is strong evidence supporting the importance of peptidoleukotrienes in this disease . Likewise, the biochemical pharmacology of inflammatory bowel disease (IBD) suggests an important role for 5-LO products in the pathophysiology of this group of diseases.…”

Section: Introductionmentioning

confidence: 99%

Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea

et al. 1996

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A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in the mouse of selected compounds was assessed using an ex vivo LTB4 assay and an adoptive peritoneal anaphylaxis assay at extended pretreat times. Compounds with an extended duration of action were re-examined as the individual enantiomers in the ex vivo assay, and the (S) enantiomer of N-hydroxy-N-[2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl]urea, (+)-1a (SB 202235), was selected as the compound with the best overall profile. Higher plasma concentrations and longer plasma half-lives were found for (+)-1a relative to its enantiomer in the mouse, monkey, and dog. In vitro metabolic studies in mouse liver microsomes established enantiospecific glucuronidation as a likely mechanism for the observed differences between the enantiomers of 1a. Enantioselective glucuronidation favoring (-)-1a was also found in human liver microsomes.

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Pharmacology of Leukotriene Receptor Antagonists

Hay¹

1997

Chest

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Inhibition of Allergic Bronchoconstriction in Guinea Pigs and in Asthmatics by the Leukotriene Antagonist ONO-1078

Cited by 3 publications

References 4 publications

Modified Haoqin Qingdan Decoction Exerts Antioxidant Effect via Activating PI3K/Akt/Nrf2 Pathway on Allergic Asthma Mice

Modified Haoqin Qingdan Decoction Exerts Antioxidant Effect via Activating PI3K/Akt/Nrf2 Pathway on Allergic Asthma Mice

Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea

Pharmacology of Leukotriene Receptor Antagonists

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