Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer

Attia, Yasmeen M.; El‐Kersh, Dina M.; Ammar, Reham A.; Adel, Aliaa; Khalil, Aya; Walid, Hoda; Eskander, Kirullos; Hamdy, Mohamed; Reda, N. Di; Mohsen, Nour Elhoda; Al-Toukhy, Ghada M.; Mansour, Mohamed; Elmazar, Mohamed M.

doi:10.1016/j.cbi.2019.108865

Cited by 44 publications

(35 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combining PTX with vitamin D3 and curcumin could potentially synergize their ability to decrease drug resistance by decreasing P-gp. In vivo, the triple therapy group (PTX + curcumin + D3) resulted in the smallest tumor size, indicating that the addition of curcumin and D3 could enhance the therapeutic effect on the tumor (Attia et al, 2020).…”

Section: Approaches For Studying the Interaction Of P-gp And Tcmmentioning

confidence: 98%

The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

et al. 2020

View full text Add to dashboard Cite

As a member of the ATP-dependent membrane transport proteins, P-Glycoprotein (P-gp) is known to pump substrates out of cells using an ATP-dependent mechanism. The overexpression of P-gp in tumor cells reduces the intracellular drug concentrations, which decreases the efficacy of extensive antitumor drugs and leads to multidrug resistance (MDR) clinically. The combination of anticancer drugs with P-gp inhibitor has been an attractive and promising strategy to reverse MDR in cancer treatment. However, nonspecific or nonselective distribution of P-gp inhibitors to nontarget organs is one of the most fatal shortcomings in clinical application. Thus, there is an urgent need for effective and nontoxic MDR reversal agents, particularly in P-gp-mediated MDR. Traditional Chinese medicine (TCM) natural products may prove less toxic for use in P-gp inhibition to promote MDR reversal. P-gp modulatory effects have been previously demonstrated using selected TCM, including the flavonoid, alkaloid, terpenoid, coumarin, and quinonoid compounds, and some Chinese medicine extracts. Moreover, the approaches for screening active components from TCM are necessary, and these approaches face challenges. At present, the approaches to study the interaction between TCM and P-gp are divided into in vitro, in vivo, and in silico methods. This review will provide an overview and update on the role of TCM in overcoming P-gp-mediated MDR and the approaches to study the interaction between TCM and P-gp. SIGNIFICANCE STATEMENT This review summarized some traditional Chinese medicines identified to have a modulatory effect on P-gp, including flavonoids, alkaloids, terpenoids, coumarins, quinonoid compounds, and some Chinese medicine extracts, and it introduced possible mechanisms. The approaches to study the interaction between TCM and P-gp are divided into in vitro, in vivo, and in silico methods.

show abstract

Section: Approaches For Studying the Interaction Of P-gp And Tcmmentioning

confidence: 98%

The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is worth mentioning that curcumin is capable of affecting drug transporters in enhancing sensitivity of cancer cells to paclitaxel chemotherapy. In this way, curcumin reduces activity and expression of p-glycoprotein (P-gp) and multidrug resistance-1 (MDR1) to promote paclitaxel accumulation in cancer cells [64]. Nanotechnology can provide a platform for codelivery of curcumin and paclitaxel.…”

Section: Curcumin In Cancer Chemotherapy: Beyond Doxorubicinmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

View full text Add to dashboard Cite

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

show abstract

“…Besides, the upregulation of exosomal miR-93 in ductal carcinoma in situ (DCIS) patients is a prognostic signature of breast tumors [185]. One of the troublesome problems faced in cancer therapy is the resistance of cancer cells to chemotherapeutic agents [186,187]. Expression evaluation of miR-93 in breast cancer cell lines showed that miR-93 undergoes down-regulation in these tumor cells.…”

Section: Breast Cancermentioning

confidence: 99%

“…Expression evaluation of miR-93 in breast cancer cell lines showed that miR-93 undergoes down-regulation in these tumor cells. Enhancing the expression of miR-93 is associated with high anti-tumor activity of chemotherapeutic agents by reducing the expression of Bcl-2 and P-glycoprotein (P-gp) [188]. Accumulating data demonstrates that miRs contribute to the stimulation of EMT in breast cancer [189][190][191][192].…”

Section: Breast Cancermentioning

confidence: 99%

Flaming the fight against cancer cells: the role of microRNA-93

et al. 2020

View full text Add to dashboard Cite

There have been attempts to develop novel anti-tumor drugs in cancer therapy. Although satisfying results have been observed at a consequence of application of chemotherapeutic agents, the cancer cells are capable of making resistance into these agents. This has forced scientists into genetic manipulation as genetic alterations are responsible for generation of a high number of cancer cells. MicroRNAs (miRs) are endogenous, short non-coding RNAs that affect target genes at the post-transcriptional level. Increasing evidence reveals the potential role of miRs in regulation of biological processes including angiogenesis, metabolism, cell proliferation, cell division, and cell differentiation. Abnormal expression of miRs is associated with development of a number of pathologic events, particularly cancer. MiR-93 plays a significant role in both physiological and pathological mechanisms. At the present review, we show how this miR dually affects the proliferation and invasion of cancer cells. Besides, we elucidate the oncogenesis or oncosuppressor function of miR-93.

show abstract

Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer

Cited by 44 publications

References 42 publications

The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Flaming the fight against cancer cells: the role of microRNA-93

Contact Info

Product

Resources

About