Inhibition of action of pituitary hormones by animal sera

Abstract

The experiments were aided by a grant from the Josiah Macy, jr., Foundation. * Mentioned because of the possible relationship to the formation of immune bodies This applies also to extract No. 5.

The specificity of antigonadotropic sera

“…Thompson and Cushing (1937) found that the antiserum to extract of pregnant mare serum, prepared in a dog, would only partially inhibit the gonadotropic activity of an extract of sheep or pig pituitary, or of human urine of pregnancy. The serum of two dogs immunized with extract of sheep pituitary was less specific, and neutralized extracts of pig pituitary, human urine of pregnancy, human urine of menopause and pregnant mare serum.…”