Inhibition of acetylcholinesterase in the gut inhibits schedule-controlled behavior in the rat

Brezenoff, Henry E.; McGee, John; Hymowitz, Norman

doi:10.1016/0024-3205(85)90624-1

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…In addition, ACh is involved in regulating several functions such as gut motility, local blood flow, intestinal mucosal barrier permeability and inflammation regulation [51][52][53]. Furthermore, it has been shown that ChE inhibition by soman, neostigmine, PB or DFP alters intestinal functions [54][55][56]. The intestine also plays a crucial role in the elimination of NA [57], which should impact the microbiota homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure

François¹,

Mondot

Gerard

et al. 2022

Biomedicines

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Anxiety disorder is one of the most reported complications following organophosphorus (OP) nerve agent (NA) exposure. The goal of this study was to characterize the long-term behavioral impact of a single low dose exposure to 4-nitrophenyl isopropyl methylphosphonate (NIMP), a sarin surrogate. We chose two different sublethal doses of NIMP, each corresponding to a fraction of the median lethal dose (one mild and one convulsive), and evaluated behavioral changes over a 6-month period following exposure. Mice exposed to both doses showed anxious behavior which persisted for six-months post-exposure. A longitudinal magnetic resonance imaging examination did not reveal any anatomical changes in the amygdala throughout the 6-month period. While no cholinesterase activity change or neuroinflammation could be observed at the latest timepoint in the amygdala of NIMP-exposed mice, important modifications in white blood cell counts were noted, reflecting a perturbation of the systemic immune system. Furthermore, intestinal inflammation and microbiota changes were observed at 6-months in NIMP-exposed animals regardless of the dose received. This is the first study to identify long-term behavioral impairment, systemic homeostasis disorganization and gut microbiota alterations following OP sublethal exposure. Our findings highlight the importance of long-term care for victims of NA exposure, even in asymptomatic cases.

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Section: Discussionmentioning

confidence: 99%

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure

François¹,

Mondot

Gerard

et al. 2022

Biomedicines

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“…Minor effects on rat behavior were observed in similar experiments with low Vx concentrations (9). Subcutaneous injection of soman at a dose of 80 micrograms / kg suppresses this ability (10).…”

Section: Expositionmentioning

confidence: 99%

Behavioral changes of laboratory animals intoxicated with chemical weapons

Bozakova¹,

Ivanov²

2018

TJS

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Chemical weapons have been used repeatedly in the history of humanity for wars and terrorist acts. They have caused major insults on human health and taken many lives. The most frequent tests for the effects of chemical weapons involve various laboratory animals that are known to experience behavioral changes and disorders. The purpose of this overview is to examine the most frequent changes and disorders in the behavior of laboratory animals-mice, rats, guinea pigs, cats, and various primates intoxicated with chemical weapons.

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Effect of soman on schedule-controlled behavior and brain acetylcholinesterase in rats

1985

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Inhibition of acetylcholinesterase in the gut inhibits schedule-controlled behavior in the rat

Cited by 9 publications

References 9 publications

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure

Behavioral changes of laboratory animals intoxicated with chemical weapons

Effect of soman on schedule-controlled behavior and brain acetylcholinesterase in rats

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