Inhibition of 5-HT Neurotransmission Increases Clonidine Protective Effects on Naloxone-induced Conditioned Place Aversion in Morphine-dependent Rats

Caillé, Stéphanie; Stinus, Luis; Fernández-Espejo, Emilio; Deurwaerdère, Philippe De; Spampinato, Umberto; Koob, George F.

doi:10.1038/sj.npp.1300033

Cited by 16 publications

(7 citation statements)

References 39 publications

(42 reference statements)

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“…Moreover, all animals also displayed a clear preference for the compartment associated with saline injection as shown previously (Caille et al , 2003). In classical fear conditioning studies in drug-naive animals, the absence of negative outcome following a neutral stimulus is also known to lead to safety learning and specific neurophysiological responses (Genud-Gabai et al , 2013; Likhtik et al , 2014).…”

Section: Discussionsupporting

confidence: 82%

“…Our paradigm models these last two aspects but cannot directly address questions related to the substance rewarding properties. As our chronic morphine treatment induced tolerance (Gold et al , 1994), it is likely that preference for the CS− compartment (also previously shown in Caille et al , 2003 with the same naloxone dose) develops with the progressive perception of the absence of withdrawal as an increasing safety signal. Preclinical studies have shown that conditioned opiate withdrawal reinstate morphine conditioned place preference (Lu et al , 2005) and reactivation of opiate withdrawal memories indeed plays a role in drug seeking (Hellemans et al , 2006a, 2006b; Kenny et al , 2006).…”

Section: Discussionmentioning

confidence: 60%

“…Opiate withdrawal can induce a mild to severe somatic syndrome together with the formation of long-lasting aversive memories driven by the association of stimuli, contexts, and emotions related to withdrawal itself (Frenois et al , 2005a). In parallel to these negative associative memories, morphine-dependent subjects can also distinguish cues and contexts that consistently signal the absence of withdrawal and form associative memories based on these perceived safety signals (Caille et al , 2003; Leknes et al , 2011). Such emotional memories are considered as a key component in the addiction process in that they motivate drug seeking and further promote maladaptive behaviors such as sustained drug taking or relapse in abstinent subjects (Milton and Everitt, 2012; Torregrossa et al , 2011).…”

Section: Introductionmentioning

confidence: 99%

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Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens

Déjean

Sitko

Girardeau

et al. 2016

Neuropsychopharmacol

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Affective memories associated with the negative emotional state experienced during opiate withdrawal are central in maintaining drug taking, seeking, and relapse. Nucleus accumbens (NAC) is a key structure for both acute withdrawal and withdrawal memories reactivation, but the NAC neuron coding properties underpinning the expression of these memories remain largely unknown. Here we aimed at deciphering the role of NAC neurons in the encoding and retrieval of opiate withdrawal memory. Chronic single neuron and local field potentials recordings were performed in morphine-dependent rats and placebo controls. Animals were subjected to an unbiased conditioned placed aversion protocol with one compartment (CS+) paired with naloxone-precipitated withdrawal, a second compartment with saline injection (CS−), and a third being neutral (no pairing). After conditioning, animals displayed a typical place aversion for CS+ and developed a preference for CS− characteristic of safety learning. We found that distinct NAC neurons code for CS+ or CS−. Both populations also displayed highly specific oscillatory dynamics, CS+ and CS− neurons, respectively, following 80 Hz (G80) and 60 Hz (G60) local field potential gamma rhythms. Finally, we found that the balance between G60 and G80 rhythms strongly correlated both with the ongoing behavior of the animal and the strength of the conditioning. We demonstrate here that the aversive and preferred environments are underpinned by distinct groups of NAC neurons as well as specific oscillatory dynamics. This suggest that G60/G80 interplay—established through the conditioning process—serves as a robust and versatile mechanism for a fine coding of the environment emotional weight.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens

Déjean

Sitko

Girardeau

et al. 2016

Neuropsychopharmacol

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“…Caillé et al . (2003b) examined the interaction between the serotonergic and the noradrenergic system with respect to naloxone‐precipitated withdrawal‐induced CPA.…”

Section: Studies Examining the Effects Of Lesions (See Also Table 7)mentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

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“…Se extirpó el cerebro y se diseccionó bajo microscopio la corteza, estriado e hipocampo, y se almacenaron a -80ºC. Los niveles de serotonina, noradrenalina y dopamina se midieron posteriormente mediante un sistema de cromatografía líquida de alta resolución siguiendo la metodología habitual (Caillé et al, 2003).…”

Section: Medición De Los Niveles Tisulares De Aminas Biógenasunclassified

Full number: Volume 3, Number 1 / Número completo: Volumen 3, Número 1

2003.¹

2003

HAAJ

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Inhibition of 5-HT Neurotransmission Increases Clonidine Protective Effects on Naloxone-induced Conditioned Place Aversion in Morphine-dependent Rats

Cited by 16 publications

References 39 publications

Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens

Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Full number: Volume 3, Number 1 / Número completo: Volumen 3, Número 1

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