Inhibition is associated with whole-brain structural brain connectivity on network level in school-aged children born very preterm and at term

Disselhoff, Vera; Jakab, András; Schnider, Barbara; Latal, Beatrice; Wehrle, Flavia M.; Hagmann, Cornelia

doi:10.1016/j.neuroimage.2020.116937

Cited by 6 publications

(7 citation statements)

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“…In a previous study in pretermborn children at school age, we detected group differences in one subdomain of inhibition abilities, namely, in response inhibition, but neither in interference control nor overall inhibition abilities. 51 This is in line with existing research. 33,42,45,46,[52][53][54] To better understand the complexity of inhibition problems in children born very preterm, the exploration of their neural correlates is indispensable.…”

Section: Introductionsupporting

confidence: 91%

“…70 Detailed methods on the assessment of inhibition abilities in this cohort have been reported previously. 51 Two standardized tasks were administered in random order examining the key functions of inhibition abilities:…”

Section: Neurodevelopmental Assessmentmentioning

confidence: 99%

“…However, group differences in inhibition abilities were not explained by different strengths of these structural connections. 51 In typically developing individuals, metaanalytic evidence shows functional brain connectivity in a large-scale distributed brain network to be associated with inhibition abilities. 56 FMRI at resting state (rsfMRI) assesses brain activity in the absence of deliberate activity or external stimulation, allowing the description of intrinsic functional brain networks showing synchronous, spontaneous neuronal activity.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children

Disselhoff,

Jakab,

Latal

et al. 2024

Pediatr Res

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Background Inhibition abilities are known to have impact on self-regulation, behavior, and academic success, and they are frequently impaired in children born preterm. We investigated the possible contributions of resting-state functional brain connectivity to inhibition following preterm birth. Methods Forty-four preterm and 59 term-born participants aged 8–13 years were administered two inhibition tasks and resting-state functional MRI was performed. Functional connectivity (FC) networks were compared between groups using network-based statistics. Associations of FCNs and inhibition abilities were investigated through multivariate linear regression models accounting for the interaction between birth status and inhibition. Results NBS revealed weaker FC in children born preterm compared to term-born peers in connections between motor and supplementary motor regions, frontal lobe, precuneus, and insula. Irrespective of birth status, connections between the cerebellum, frontal, and occipital lobes and inter-lobar, subcortical, intra-hemispheric long-range connections were positively correlated with one of the two inhibition tasks. Conclusions Preterm birth results in long-term alterations of FC at network level but these FCN alterations do not specifically account for inhibition problems in children born very preterm. Impact Irrespective of birth status, significant associations were found between the subdomain of response inhibition and functional connectivity in some subnetworks. A group comparisons of functional brain connectivity measured by rsfMRI in school-aged children born very preterm and at term. The investigation of network-level functional connectivity at rest does not appear adequate to explain differences in inhibition abilities between children born very preterm and at term, hence other imaging techniques might be more suited to explore the underlying neural mechanisms of inhibition abilities in school-aged children born very preterm.

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Section: Introductionsupporting

confidence: 91%

Section: Neurodevelopmental Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children

Disselhoff,

Jakab,

Latal

et al. 2024

Pediatr Res

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“… 32 In fact, a considerable number of studies report on long-term adverse effects of very preterm birth on white matter microstructure throughout childhood and adolescence 82 , 83 related to executive function abilities using diffusion tensor imaging. 9 , 84 – 87 …”

Section: Discussionmentioning

confidence: 99%

Altered brain metabolism contributes to executive function deficits in school-aged children born very preterm

et al. 2020

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Background Executive function deficits in children born very preterm (VPT) have been linked to anatomical abnormalities in white matter and subcortical brain structures. This study aimed to investigate how altered brain metabolism contributes to these deficits in VPT children at school-age. Methods Fifty-four VPT participants aged 8–13 years and 62 term-born peers were assessed with an executive function test battery. Brain metabolites were obtained in the frontal white matter and the basal ganglia/thalami, using proton magnetic resonance spectroscopy (MRS). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, glutamate + glutamine (Glx)/Cr, and myo-Inositol (mI)/Cr were compared between groups and associations with executive functions were explored using linear regression. Results In the frontal white matter, VPT showed lower Glx/Cr (mean difference: −5.91%, 95% CI [−10.50, −1.32]), higher Cho/Cr (7.39%, 95%-CI [2.68, 12.10]), and higher mI/Cr (5.41%, 95%-CI [0.18, 10.64]) while there were no differences in the basal ganglia/thalami. Lower executive functions were associated with lower frontal Glx/Cr ratios in both groups (β = 0.16, p = 0.05) and higher mI/Cr ratios in the VPT group only (interaction: β = −0.17, p = 0.02). Conclusion Long-term brain metabolite alterations in the frontal white matter may be related to executive function deficits in VPT children at school-age. Impact Very preterm birth is associated with long-term brain metabolite alterations in the frontal white matter. Such alterations may contribute to deficits in executive function abilities. Injury processes in the brain can persist for years after the initial insult. Our findings provide new insights beyond structural and functional imaging, which help to elucidate the processes involved in abnormal brain development following preterm birth. Ultimately, this may lead to earlier identification of children at risk for developing deficits and more effective interventions.

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“…En somme, la version originale pour adultes du test de Hayling possède de bonnes qualités psychométriques et plusieurs études documentent l'utilité clinique de la version pédiatrique, notamment auprès des enfants qui présentent un TDAH et un trouble développemental de la coordination. Il pourrait être employé auprès des populations cliniques qui présentent des atteintes sur le plan des processus d'inhibition, notamment chez les enfants présentant un syndrome Gilles de la Tourette (SGT) (Morand-Beaulieu, 2017), un trouble du spectre de l'autisme (Adams, 2012), qui ont souffert d'un traumatisme craniocérébral (Sinopoli et Dennis, 2012) et chez les enfants nés prématurément (Disselhoff et al, 2020). C'est un outil qui pourrait également s'avérer très pertinent en recherche pour documenter le développement de l'inhibition et plus précisément de l'inhibition verbale chez l'enfant.…”

Section: Introductionunclassified

Pré-validation et normes préliminaires du test de Hayling Junior pour évaluer l’inhibition verbale chez l’enfant francophone au Québec

Racicot

Leclerc

Gauthier

2022

NCACN

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Le test de Hayling mesure l’inhibition verbale et est largement utilisé chez l’adulte. Les données psychométriques sont restreintes pour la version Junior et les normes pour les enfants québécois sont inexistantes. L’objectif de cette étude était de produire des normes préliminaires du Test de Hayling Junior pour les enfants québécois selon certaines variables sociodémographiques et de mesurer la fidélité et la validité de ce test. L’échantillon était composé de 32 participants (14 filles, 18 garçons) âgés de 8 à 12 ans (M=9,47, É.-T.=1,32). L’âge était corrélé aux scores de vitesse et les scores ne variaient pas selon le sexe ou le niveau d’éducation des parents. Les indices de fidélité étaient généralement adéquats. Les scores au Hayling Junior étaient corrélés à certaines mesures de l’inhibition, mais pas à la mémoire de travail ni à l’échelle hyperactivité/impulsivité d’un questionnaire pour parent. Ce test permettra aux cliniciens d’évaluer l’inhibition verbale et contribuera à l’étude de son développement chez l’enfant québécois. The Hayling test measures verbal inhibition and is widely used with adults. Psychometric data is limited for the Junior version and norms for the Quebec pediatric population are non-existent. The aim of this study was to produce norms for the Hayling Junior Test for Quebec children according to certain socio-demographic variables and to measure the reliability and validity of this test. The sample consisted of 32 participants (14 girls, 18 boys) aged 8 to 12 years (M = 9.47, SD = 1.32). Age was correlated with speed scores and scores did not vary according to sex or parental education level. The fidelity indices were generally adequate. Hayling Junior's scores correlated with some measures of inhibition, but not with working memory or the hyperactivity / impulsivity scale of a questionnaire for parent. This test will allow clinicians to assess verbal inhibition and will aid in the study of its development with Quebec children.

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Inhibition is associated with whole-brain structural brain connectivity on network level in school-aged children born very preterm and at term

Cited by 6 publications

References 121 publications

Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children

Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children

Altered brain metabolism contributes to executive function deficits in school-aged children born very preterm

Pré-validation et normes préliminaires du test de Hayling Junior pour évaluer l’inhibition verbale chez l’enfant francophone au Québec

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