Inhibition Effects of Some Lignans on Carbonic Anhydrase, Acetylcholinesterase and Butyrylcholinesterase Enzymes Leyla Polat Köse and İlhami Gülçin

Abstract

Lignans are a large group of chemical compounds found in plants. They have effects on enzymes, protein synthesis, cell proliferation, angiogenesis, growth factor and cell differentiation. In this study, inhibition effects of α-(-)-conidendrin, enterodiole, enterolactone, nordihydroguaiaretic acid, secoisolariciresinol and secoisolariciresinol diglucoside against carbonic anhydrase I and II isoenzymes (CA I, and II) and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The Ki values of the lignans were found to be in the ranges of 1.27-3.30 nM for CA I, 1.11-2.68 nM for CA II, 0.72-1.62 nM for AChE, and 0.08-0.20 nM for AChE.

Novel N‐propylphthalimide‐ and 4‐vinylbenzyl‐substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes

“…For designation of both isoforms purity, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) was performed after a purification stage. The purity and presence of both isoforms were performed by SDS‐PAGE . After this work, a single band was seen for each isoforms.…”

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study

“…This affected us to focus novel AChEIs from medicinal plants. On the other hand, the extension of specific and potent inhibitors of butyrylcholinesterase (BChE) have found too much attention as a potential therapeutic in the reduction of neurodegenerative diseases …”

The toxicological effects of some avermectins on goat liver carbonic anhydrase enzyme

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