Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies

Anti-inflammatory of disenecionyl cis-khellactone in LPS-stimulated RAW264.7 cells and the its inhibitory activity on soluble epoxide hydrolase

“…Especially, sEH is highly expressed in LPS-stimulated lung macrophages [ 13 ]. Therefore, sEH has been known as a target for anti-inflammatory treatment, and researchers are continuously striving to develop natural inhibitors to replace urea-type sEH inhibitors [ 15 , 16 ].…”

Inhibitory Activity of Natural cis-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells

“…Recently, urea-type derivatives were found to be potential sEH inhibitors [15]. To maintain the concentration of EETs, research into inhibiting the catalytic reaction of sEH is ongoing [16]. To overcome challenges such as the low solubility and poor metabolic stability of urea-type inhibitors [15], compounds like flavonoids from Inula britanica [17], triterpenoids from Alisma orientale [18], and amine-alkaloids from Scutellaria baicalensis [19] are under investigation.…”