Inhibition de l’apprentissage et de la mémoire par les anesthésiques généraux

Wang, Dian-Shi; Orser, Beverley A.

doi:10.1007/s12630-010-9428-8

Cited by 49 publications

(36 citation statements)

References 149 publications

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“…Earlier investigations have reported the impact of anesthesia towards profound cognitive impairment in learning and memory leading to defects in brain function at various levels [14]. Similarly, we observed significantly decreased level of spatial learning, neural growth factors and alterations of pro-inflammatory markers in rats exposed to anesthesia (thiopental) with normal diet (group Ib) than that of non-exposed normal-fed (group Ia) animals.…”

Section: Discussionsupporting

confidence: 77%

Dietary Cholesterol Protects Anesthesia-Induced Cognitive Deficits in Wistar Rats

Chen¹,

Liu²,

Yang³

et al. 2015

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 77%

Dietary Cholesterol Protects Anesthesia-Induced Cognitive Deficits in Wistar Rats

Chen¹,

Liu²,

Yang³

et al. 2015

Trop. J. Pharm Res

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“…Regions selected for the seed-based analysis were the right anterior insular cortex (33,22,6), thalamus (À7, À16, 6 and 7, À16, 6 combined), mesencephalon (À2, À24, À8), PTA (À3, À18, À27), and hippocampus (25, À16, À15). Literature confirms strong relationships of these regions with cognition and consciousness: the PTA, mesencephalon, and thalamus are of interest because of their roles in cortex activation and coordination (Abulafia et al, 2009;Saper et al, 2005;Schiff, 2008), while the hippocampus has a pivotal role in memory processing and has a close association with the DMN, providing additional information about DMN integrity (Wang and Orser, 2011). The right anterior insular cortex has been associated with the making of go/no-go decisions (Aron et al, 2004;Duann et al, 2009) and is part of the salience network, which is thought to enable switching between internally-oriented thought (DMN-driven) and externally-oriented activity (ECN-driven) (Seeley et al, 2007).…”

Section: Seed-based Analysismentioning

confidence: 97%

Thalamus, Brainstem and Salience Network Connectivity Changes During Propofol-Induced Sedation and Unconsciousness

et al. 2013

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In this functional magnetic resonance imaging study, we examined the effect of mild propofol sedation and propofol-induced unconsciousness on resting state brain connectivity, using graph analysis based on independent component analysis and a classical seed-based analysis. Contrary to previous propofol research, which mainly emphasized the importance of connectivity in the default mode network (DMN) and external control network (ECN), we focused on the salience network, thalamus, and brainstem. The importance of these brain regions in brain arousal and organization merits a more detailed examination of their connectivity response to propofol. We found that the salience network disintegrated during propofol-induced unconsciousness. The thalamus decreased connectivity with the DMN, ECN, and salience network, while increasing connectivity with sensorimotor and auditory/insular cortices. Brainstem regions disconnected from the DMN with unconsciousness, while the pontine tegmental area increased connectivity with the insulae during mild sedation. These findings illustrate that loss of consciousness is associated with a wide variety of decreases and increases of both cortical and subcortical connectivity. It furthermore stresses the necessity of also examining resting state connectivity in networks representing arousal, not only those associated with awareness.

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“…The difficulties in maintaining the proper level of general anesthesia arise from complex mechanisms involved in the physiology of dreams and consciousness 1,2 , the multidirectional (including cardiodepressive) mechanisms of action of anesthetics 3,4 , differences in pharmacokinetics and pharmacodynamics of anesthetics, genetic variability of patients 5,6 as well as from experience of the anesthesiologist. Implicit and explicit recalls after procedure, resulting from too low level of anesthesia, may cause posttraumatic stress disorder (PTSD) and both acute and chronic mental disorders.…”

Section: Introductionmentioning

confidence: 99%

Non-instrumental clinical monitoring does not guarantee an adequate course of general anesthesia. A prospective clinical study

Szostakiewicz¹,

Rybicki²,

Tomaszewski³

2018

BIOMED PAP

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Background. Clinical monitoring is the most common method of adjusting the appropriate level of general anesthesia. However, episodes of intraoperative awareness (AWR) are still reported, suggesting that clinical observations may not be sufficient in some cases. The objective of this study was to compare the efficacy of clinical and instrumental neuromonitoring with auditory evoked potentials (AEP) in an intraoperative analysis of the proper level of general anesthesia. Methods. Patients scheduled for elective surgery were randomly divided into two groups. Subjects in the first group underwent intravenous, in the second group volatile anesthesia. The adequacy of anesthesia was analyzed using clinical parameters. All the participants were instrumentally monitored with the autoregressive AEP index (AAI). After the anesthesia, patients filled out a questionnaire on possible AWR. Results. Data of 208 patients (87 in the first, and 121 in the second group) were analyzed. Before surgery there were no changes in AAI values between groups (80 vs. 78, P=0.5192). The mean values of clinical parameters changed, but five minutes after the nociceptive stimuli. The mean values of AAI at analyzed time points were specific for general anesthesia. In patients under intravenous anesthesia, we found more episodes of too low (46/608 vs.15/847, P<0.000) anesthesia. One case of AWR was found in the TIVA group. Conclusions. AAI index is good indicator of patients' level of consciousness during general anesthesia. Standard clinical monitoring provides appropriate level of the procedure. However, it is insufficient during TIVA and does not prevent episodes of AWR.

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Inhibition de l’apprentissage et de la mémoire par les anesthésiques généraux

Cited by 49 publications

References 149 publications

Dietary Cholesterol Protects Anesthesia-Induced Cognitive Deficits in Wistar Rats

Dietary Cholesterol Protects Anesthesia-Induced Cognitive Deficits in Wistar Rats

Thalamus, Brainstem and Salience Network Connectivity Changes During Propofol-Induced Sedation and Unconsciousness

Non-instrumental clinical monitoring does not guarantee an adequate course of general anesthesia. A prospective clinical study

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