Inhibition by various steroids on dihydrotestosterone binding to androphilic protein in human benign prostatic hypertrophy.

Properties of Androphilic Proteins in Cytosols of Human Benign Prostatie Hypertrophy

“…As reported previously (Kodama et al, , 1978, Sephadex chromatography of the30-50% fraction of delipidized cytosol separated two androphilic proteins; one eluted in Vo fraction and the other in IgG fraction.…”

“…In the previous reports from this laboratory, it was reported that the binding of the androphilic proteins in the Vo and the IgG fractions to dihydrotestosterone was inhibited by the addition of other steroids, but the inhibition rate by competitors was different in these two androphilic proteins Kodama et al, 1978). In the present experiments, differences on the binding affinity and capacity to nuclei were observed in the two andro- Vol.26,No.4 ANDROPHILIC PROTEIN 457 philic proteins.…”

Binding of chlormadinone acetate to cytosol from human benign prostatic hypertrophy.

“…This compound exhibited an inhibitory effect on the binding of dihydrotestosterone to human prostatic cytosol (Kodama et al 1978 …”