Inhibition by tannic acid of succinate and malate translocation across the mitochondrial membrane

Luciani, Sisto

doi:10.1016/0006-2952(73)90041-5

Biochemical Pharmacology

1973

DOI: 10.1016/0006-2952(73)90041-5

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Inhibition by tannic acid of succinate and malate translocation across the mitochondrial membrane

Sisto Luciani

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1977

1992

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Cited by 5 publications

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“…biological and pharmacological activities (1)(2)(3)(4)(5); among these, anti-secretory and anti-ulcerogenic effects have been reported. A crude extract from Linderae ramus, of which the main constituent is tannin, has been shown to be effective in various kinds of experimental ulcer models in rats (6).…”

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Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Murakami

Muramatsu²,

Otomo³

1992

J. Nat. Prod.

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The effect of tannic acid on gastric H+,K(+)-ATPase was studied. Tannic acid dose-dependently inhibited pig gastric H+,K(+)-ATPase activity with an IC50 value of 2.9 x 10(-8) M. Tannic acid also inhibited K(+)-stimulated p-nitrophenyl phosphatase (K(+)-pNPPase) activity, which is found in gastric H+,K(+)-ATPase preparations, as well as H+,K(+)-ATPase activity, with an IC50 value of 4.1 x 10(-7) M. Kinetic studies showed that the inhibition of H+,K(+)-ATPase activity by tannic acid was competitive with respect to ATP and noncompetitive with respect to K+. These results show that tannic acid is a potent inhibitor of gastric H+,K(+)-ATPase; this may be related to its anti-secretory and anti-ulcerogenic effects.

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confidence: 99%

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Murakami

Muramatsu²,

Otomo³

1992

J. Nat. Prod.

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Effects of N-chlorobenzyl analogues of amiloride on myocardial contractility, Na-Ca-exchange carrier and other cardiac enzymatic activities

Floreani

Tessari

Debetto

et al. 1987

Naunyn-Schmiedeberg's Arch Pharmacol

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1. In electrically driven guinea pig left atria, micromolar concentrations (2 mumol/l to 80 mumol/l) of N-chlorobenzyl derivatives of amiloride (o-chlorobenzamil and 3',4'-dichlorobenzamil) produced quantitatively similar positive inotropic effects. Contracture developed with 3',4'-dichlorobenzamil. Endogenously released catecholamines contributed 30% to the positive inotropic effect of o-chlorobenzamil but did not contribute at all to the effect of 3',4'-dichlorobenzamil. When tested in the presence of the inhibitor of phosphodiesterase isobutylmethylxanthine, o-chlorobenzamil antagonized its positive inotropic effect, whereas 3',4'-dichlorobenzamil potentiated it. o-Chlorobenzamil also antagonized the positive inotropic effect of ouabain in that it shifted its concentration-effect curve to the right. Moreover, o-chlorobenzamil prevented the appearance of ouabain toxicity in terms of a rise in the resting force. 2. Also, in electrically driven guinea pig papillary muscle, micromolar concentrations (5 mumol/l to 30 mumol/l) of both N-chlorobenzyl derivatives of amiloride produced a positive inotropic effect. This effect was more marked with 3',4'-dichlorobenzamil than with o-chlorobenzamil and was associated for both compounds with lengthening of relaxation time. 3. o-Chlorobenzamil and 3',4'-dichlorobenzamil influenced, though not to the same extent, several systems involved in the onset and in the control of cardiac contractility. 3',4'-Dichlorobenzamil inhibited with the same potency Na-K-ATPase, sarcotubular Ca-ATPase, Na-Ca-exchange carrier, cAMP-dependent phosphodiesterase isolated from bovine heart and oxidative phosphorylation of mitochondria isolated from rat liver. Low micromolar concentrations of o-chlorobenzamil mainly inhibited Na-Ca-exchange carrier and cAMP-dependent phosphodiesterase.(ABSTRACT TRUNCATED AT 250 WORDS)

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The tannery industrial effluent effect on succinate dehydrogenase activity pattern in a freshwater snail,Pila globosa

Rao

Kumar

1982

Proc Ani Sci

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Inhibition by tannic acid of succinate and malate translocation across the mitochondrial membrane

Cited by 5 publications

References 33 publications

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Effects of N-chlorobenzyl analogues of amiloride on myocardial contractility, Na-Ca-exchange carrier and other cardiac enzymatic activities

The tannery industrial effluent effect on succinate dehydrogenase activity pattern in a freshwater snail,Pila globosa

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Inhibition by tannic acid of succinate and malate translocation across the mitochondrial membrane

Cited by 5 publications

References 33 publications

Inhibitory Effect of Tannic Acid on Gastric H+,K+-ATPase

Inhibitory Effect of Tannic Acid on Gastric H+,K+-ATPase

Effects of N-chlorobenzyl analogues of amiloride on myocardial contractility, Na-Ca-exchange carrier and other cardiac enzymatic activities

The tannery industrial effluent effect on succinate dehydrogenase activity pattern in a freshwater snail,Pila globosa

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Product

Resources

About

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase