Inhibition by Reserpine of Histological Changes Induced by Hypertonic Saline in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus Murinus L.

Kulshreshtha, A; Dominic, C. J.

doi:10.1677/joe.0.0500707

Cited by 4 publications

(3 citation statements)

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“…The morphology of the HNS of Suncus murinus (Kulshreshtha and Dominic, 1971) conforms in all essential respects to that described for other mammalian species. Even though there are occasional individual variations in the quantity of NSM in the HNS, the perikarya of the neurosecretory cells ( Fig.…”

Section: Resultssupporting

confidence: 73%

“…The only noticeable difference is that unlike the situation prevailing in all mammalian species so far investigated, in Suncus, it is the PVN and not the SON which is primarily affected by chronic dehydration. This may perhaps indicate that in Suncus the PVN may be the more important site of ADH production (Kulshreshtha and Dominic, 1971). Administration of CPZ (Groups 3, 4 and 5) completely inhibited the appearance of the histological changes that normally follow administration of hypertonic saline.…”

Section: Discussionmentioning

confidence: 95%

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Chlorpromazine Inhibition of Dehydration-Induced Histological Changes in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus murinus L.

Kulshreshtha

Dominic

1971

Endocrinol Japon

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SynopsisThe effect of chlorpromazine (CPZ) on the histology of the hypothalamic neurosecretory system (HNS) was investigated in Suneus murinus L. which were injected with hypertonic saline. Chronic saline treatment brought about characteristic histological changes in the neurons of the paraventricular nucleus (PVN) and depletion of neurosecretory material (NSM) from the cytoplasm, stalk median eminence (SME) and the neural lobe (NL). Acute saline treatment affected the neurons of both the PVN and the supraoptic nucleus (SON); there was no detectable depletion of NSM from SME and NL. Pretreatment with or simultaneous administration of CPZ prevented the appearance of the histological changes in the HNS that normally follow chronic and acute treatments with hypertonic saline. Since the hypertonic saline-induced histological changes in the HNS are regarded as morphological manifestations of increased secretion of the antidiuretic hormone (ADH), the inhibition, by CPZ, of these changes is interpreted as providing histological evidence in favour of the diuretic effect of the drug.The available information on the effect of chlorpromazine (CPZ) on the secretion of the antidiuretic hormone (ADH) is somewhat contradictory (see Gaunt et al., 1963;de Wied, 1967). Many investigators (e.g., Kovacs et al., 1957;Bachrach et al., 1958;Supek et al., 1960;Tiwari et al., 1960;Batrinos and de Verbizier, 1962;Boris and Stevenson, 1964;Jacobson, 1965) have reported that in mammals CPZ exerts an antidiuretic effect by stimulation of ADH release from the neurohypophysis. On the other hand, others (e.g., Moyer, 1955a, b;Moyer et al., 1954;Shibusawa et al., 1955;Parrish and Levine, 1956;Kivalo et al., 1957Kivalo et al., , 1958Smith et al., 1958) have reported that CPZ has diuretic effect in mammals. It is also reported (Moses, 1964;Boris and Stevenson, 1967;Milmore and Hammerman, 1969) that CPZ blocks the antidiuretic effect which occurs in response to dehydration; however, Bachrach et al.(1958) and Scultety et al.(1958) found that CPZ was ineffective in blocking the dehydrationinduced antidiuresis.A few studies have also been made concerning the effect of CPZ on the quantity of neurosecretory material (NSM) in the hypothalamic neurosecretory system (HNS). Kivalo et al.(1958) found that administration of 25 mg of CPZ per kg for 7 days to normal rats reduced the NSM in the neural lobe (NL), but not in the supraoptic (SON) and paraventricular (PVN) nuclei. Working with lower doses (10mg per kg daily for 6 days), Bachrach et al.(1958) found that CPZ had no effect on the quantity of NSM in the neurohypophysis. Dehydration-induced depletion of NSM was not inhibited by this treatment. However, Soulairac and Soulairac (1963) reported that administration of CPZ (3 mg/day/ animal for 10 days) to rats caused an increase in the quantity of NSM in all regions

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Section: Resultssupporting

confidence: 73%

Section: Discussionmentioning

confidence: 95%

Chlorpromazine Inhibition of Dehydration-Induced Histological Changes in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus murinus L.

Kulshreshtha

Dominic

1971

Endocrinol Japon

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“…However, the effects of reserpine have been rather variable. Bridges & Thorn (1970) and Kulshreshtha & Dominic (1971) have shown that reserpine inhibited the release of vasopressin and neurosecretory material respectively while an in¬ crease in hormone secretion after administration of the drug was shown by Chaudhury et al (1962), Guzek & Lesnik (1968) and Rechardt & Hervonen (1975). Meanwhile, Dyball (1968) and Guzek et al (1976) have reported that reserpine had little or no effect on vasopressin release.…”

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confidence: 98%

Variability in neurosecretory material and responses to reserpine of the pituitary neural lobe in five strains of rat

Edwards

1980

Acta Endocrinologica

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Abstract. The levels of vasopressin and neurophysin in the neural lobe of the pituitary were measured in five strains of rat: Wistar, Sprague-Dawley, PVG, Chester Beatty and DA strains. The effect of reserpine administration (5 mg/kg body weight) was determined. There were significant differences in the weight of the neural lobe and the vasopressin and neurophysin contents of this tissue in the various strains. It was possible to show that weight of the neural lobe was not necessarily related to hormone content. The effects of reserpine also varied within the species for, while there was a fall in the vasopressin content in the Wistar and Chester Beatty strains, no change was observed in the Sprague-Dawley, PVG and DA strains. The fall in the vasopressin level in the Wistar animals was not accompanied by a simultaneous fall in the vasopressin-neurophysin content.

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Stephan¹,

Baron²,

Frahm³

1991

Insectivora

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Inhibition by Reserpine of Histological Changes Induced by Hypertonic Saline in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus Murinus L.

Cited by 4 publications

References 1 publication

Chlorpromazine Inhibition of Dehydration-Induced Histological Changes in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus murinus L.

Chlorpromazine Inhibition of Dehydration-Induced Histological Changes in the Hypothalamic Neurosecretory System of the Musk Shrew, Suncus murinus L.

Variability in neurosecretory material and responses to reserpine of the pituitary neural lobe in five strains of rat

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